Association of ABCB1 Gene Polymorphisms with Efficacy and Adverse Reaction to Risperidone or Paliperidone in Han Chinese Schizophrenic Patients  

作　　者：Weifeng Mi Feihu Liu Yongqiao Liu Bo Du Weidong Xiao Lingzhi Li Lan Huang Tianlan Lu Jia He Le Shi Weihua Yue Hongyan Zhang 

机构地区：[1]Peking University Sixth Hospital, Peking University Instituteof Mental Health, Key Laboratory of Mental Health, Ministry of Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China [2]The Mental Health Center of Xi'an, Xi'an 710061, China [3]The Sixth People's Hospital of Hebei Province,Baoding 07100, China [4]The People's Hospital of Hubei Province, Wuhan 430060,China [5]National Institute on Drug Dependence and Beijing KeyLaboratory of Drug Dependence, Peking University,Beijing 100191, China [6]Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center,Beijing 100191, China

出　　处：《Neuroscience Bulletin》2016年第6期547-549,共3页神经科学通报（英文版）

基　　金：supported by the project of Science Fund for Creative Research Groups of the National Natural Science Foundation of China(81221002);Rational Medication Application Patterns of Schizophrenia(BMU20140430) of Peking University Health Science Center

摘　　要：Dear editor, P-glycoprotein （P-gp, also known as ATP-binding cassette transport sub-family B member 1, ABCB1） is a potent ATP-dependent efflux pump for a wide variety of drugs. Although studies of its substrates are abundant [ 1, 2], and ABCB1 is a well-conserved gene, there is increasing evi- dence that its polymorphisms affect substrate specificity [3]. A previous study reported that the synonymous single nucleotide polymorphism （SNP） C3435T （rs1045642） affects the timing of co-translational folding and insertionof P-gp into the membrane,Dear editor, P-glycoprotein （P-gp, also known as ATP-binding cassette transport sub-family B member 1, ABCB1） is a potent ATP-dependent efflux pump for a wide variety of drugs. Although studies of its substrates are abundant [ 1, 2], and ABCB1 is a well-conserved gene, there is increasing evi- dence that its polymorphisms affect substrate specificity [3]. A previous study reported that the synonymous single nucleotide polymorphism （SNP） C3435T （rs1045642） affects the timing of co-translational folding and insertionof P-gp into the membrane,

关 键 词：PANSS Association of ABCB1 Gene Polymorphisms with Efficacy and Adverse Reaction to Risperidone or Paliperidone in Han Chinese Schizophrenic Patients 

分 类 号：R749.3[医药卫生—神经病学与精神病学]