透明细胞乳头状肾细胞癌5例病理特征报告并文献复习  

Clinicopathologic analysis of clear cell papillary renal cell carcinoma:our experience of five cases

作　　者：刘佳毅[1] 李尧[1] 刘佳萱 高轶[1] 吴震杰[1] 谭海颂[1] 时佳子[1] 鲍一[1] 刘冰[1] 王林辉[1] LIU Jiayi LI Yao LIU Jiaxuan GAO Yi WU Zhenjie TAN Haisong SHI Jiazi BAO Yi LIU Bing WANG Linhui(Department of Urology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China Department of Pathology, Changzheng Hospital, Second Military Medical University)

机构地区：[1]第二军医大学长征医院泌尿外科,上海200433 [2]第二军医大学长征医院病理科

出　　处：《临床泌尿外科杂志》2016年第12期1074-1077,共4页Journal of Clinical Urology

基　　金：国家自然科学基金面上项目(编号81272817)

摘　　要：目的：探讨透明细胞乳头状肾细胞癌的临床及病理特征、诊断、鉴别诊断,提高对该肾细胞癌亚型的了解。方法：收集2013年8月-2016年6月我院收治的5例透明细胞乳头状肾细胞癌患者的临床资料,重新对HE染色组织切片以及免疫组织化学切片进行光镜观察,并随访。结果：5例患者中男4例,女1例。平均年龄（61.6±15.3）（42.0-82.0）岁。平均肿瘤最大径为（3.3±1.0）（2.5-5.0）cm,除1例为pT1b期外均为pT1a期。5例患者免疫组织化学均表现为角蛋白7（CK7）、波形蛋白（Vimentin）阳性,CD10（4/5）、TFE-3（4/4）阴性。随访时间（11.4±14.9）（2.0-37.0）个月,未发现肿瘤淋巴结及远处转移,病情稳定。结论：透明细胞乳头状肾细胞癌是一种低度恶性肿瘤,目前尚未有淋巴结或远处转移的相关报道,形态上需与多种具有透明细胞和乳头状结构的肾癌鉴别,诊断这一肿瘤至少需要同时满足形态学和免疫组织化学的诊断条件。Objective：To investigate the clinicopathologic features of clear cell papillary renal cell carcinoma（CCPRCC）so as to improve the understanding of this disease.Method：From August 2013 to June 2016,five patients with CCPRCC were included.The morphologic and immunohistochemical features were studied along with clinical and follow-up information retrospectively.Result：The patients included four men and one women whose mean age was（61.6±15.3）（range,42.0-82.0）years old.Tumors were stage pT（1a）,except one pT（1b）,with a mean diameter of（3.3±1.0）（range,2.5-5.0）cm.CK7 and Vimentin were both positive in all cases,while negative reactions occurred for CD10（4/5）and TFE3（4/4）.During a mean follow-up period of（11.4±14.9）（range,2.0-37.0）months,no patient developed local recurrence,distant metastasis or cancer death.Conclusion：CCPRCC is a typically small,biologically indolent tumor without recurrence or metastasis.More attention should be paid to its accurate classification and identification from other more aggressive RCC.

关 键 词：肾细胞癌 透明细胞乳头状癌 免疫组织化学 预后 

分 类 号：R737.11[医药卫生—肿瘤]