Decidual natural killer cells and the immune microenvironment at the maternal-fetal interface  

作　　者：Binqing Fu Haiming Wei 

机构地区：[1]Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease,School of Life Science and Medical Center,University of Science and Technology of China [2]Hefei National Laboratory for Physical Sciences at Microscale,University of Science and Technology of China

出　　处：《Science China(Life Sciences)》2016年第12期1224-1231,共8页中国科学（生命科学英文版）

基　　金：supported by the Natural Science Foundation of China(91442202,81330071,81471527)

摘　　要：During early pregnancy, an orchestrated evolutionary maternal adaption toward tolerance of the semiallogeneic fetus is required to ensure decidualization and early embryo development. Remodeling of the immune system involves natural killer cells （NKs）, macrophages, T cells and dendritic cells （DCs） altering the microenvironment in the deciduas. In particular, a unique population of NK cells with a CD56brightCD16 phenotype in the decidua has been proposed to play a key role in the maternal adaptation to pregnancy. However, there is a tendency for pregnancy immunology to reflect transplantation immunology regarding the assumption that the matemal immune system should be suppressed. This tendency is misleading. We discuss how the immune system is formed in early deciduas and the interactions between maternal NK cells and fetal growth. We propose that the maternal immune response must not be fully suppressed and is even necessary for the local response of uterine NK cells.During early pregnancy,an orchestrated evolutionary maternal adaption toward tolerance of the semiallogeneic fetus is required to ensure decidualization and early embryo development.Remodeling of the immune system involves natural killer cells(NKs),macrophages,T cells and dendritic cells(DCs) altering the microenvironment in the deciduas.In particular,a unique population of NK cells with a CD56^(bright)CD16^- phenotype in the decidua has been proposed to play a key role in the maternal adaptation to pregnancy.However,there is a tendency for pregnancy immunology to reflect transplantation immunology regarding the assumption that the maternal immune system should be suppressed.This tendency is misleading.We discuss how the immune system is formed in early deciduas and the interactions between maternal NK cells and fetal growth.We propose that the maternal immune response must not be fully suppressed and is even necessary for the local response of uterine NK cells.

关 键 词：NK cells DECIDUA fetal growth the immune microenvironment 

分 类 号：R392[医药卫生—免疫学]