尿酸与脑白质高信号的相关性研究  

Relationship between serum uric acid and white matter hyperintensity

作　　者：傅君娴 陈小玲[1] 谢丽桔 郑韵秋[1] 张清香[1] 张胜[1] 王丹妮[1] 李智文[1] 蔡斌[1] Fu Junxian Chen Xiaoling Xie Liju Zheng Yunqiu Zhang Qingxiang Zhang Sheng Wang Danni Li Zhiwen Cai Bir(Department of Neurology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350000, Chin)

机构地区：[1]福建医科大学附属第一医院神经内科,福州350000

出　　处：《中华神经科杂志》2016年第12期932-935,共4页Chinese Journal of Neurology

基　　金：国家自然科学基金面上项目（81171114,81571133）;福建省卫生系统中青年骨干人才培养项目（2014-ZQN-ZD-18）;福建省自然科学基金项目（2015J01392）;国家临床重点专科建设项目;福建省临床重点专科建设项目

摘　　要：目的探讨血尿酸水平与脑白质高信号的关系。方法选择2014年1月至2015年12月就诊于福建医科大学附属第一医院、头颅MRI提示存在脑白质高信号患者177例进行横断面研究。将患者按白质病变的严重程度进行分组（ Fezakas量表评分0～1分为无或轻度组，Fezakas量表评分≥2分为中重度组），比较亚组之间的血尿酸水平和高尿酸血症发生率的差异。结果共选入脑白质病变患者177例。根据Fezakas量表评分划分脑白质高信号的解剖部位和严重程度。结果表明，深部白质高信号（ DWMH ）中重度组的血尿酸水平高于无或轻度组[分别为（345±95）μmol／L、（310±100）μmol／L，t＝1.097，P＝0.021]；校正伴发糖尿病、高脂血症、吸烟、饮酒后，年龄（OR＝1.065，95％CI 1.027～1.104，P＝0.001）、高血压（OR＝2.605，95％ CI 1.234～5.500，P＝0.012）、血尿酸水平（OR＝1.004，95％CI 1.001～1.007，P＝0.019）是脑小血管病患者中重度DWMH的独立危险因素。结论中重度DWMH与血尿酸水平有明显的关系。Objective To investigate the relationship between serum uric acid and white matter hyperintensity.Methods From January 2014 to December 2015, a cross-sectional study was conducted at the Department of Neurology of the First Affiliated Hospital of Fujian Medical University.All patients admitted to hospital with white matter hyperintensity.The patients were divided into two groups according to the severity of white matter hyperintensity.Those with Fezakas scale scores 0-1 were classified as no or mild deep white matter hyperintensity （ DWMH） group, while those with Fezakas scale scores ≥2 were classified as moderate or severe DWMH group.Serum uric acid level and the incidence of hyperuricemia were compared between groups.Results A total of 177 patients with white matter hyperintensity were enrolled into this study.The results showed that the blood uric acid level of moderate or severe DWMH group was higher than that of no or mild DWMH group （（345 ±95） μmol/L vs （310 ±100） μmol/L,t=1.097, P=0.021）.Age （OR 1.065, 95% CI 1.027-1.104, P=0.001）, hypertension （OR 2.605, 95% CI 1.234-5.500, P=0.012）, serum uric acid （OR 1.004, 95% CI 1.001 -1.007, P=0.019） were independent risk factors for moderate or severe DWMH after adjustment for diabetes , serum lipid, smoking and drinking history.Conclusion These results suggest that moderate or severe DWMH is related to serum uric acid level.

关 键 词：尿酸 高尿酸血症 脑白质高信号 深部白质高信号 

分 类 号：R743[医药卫生—神经病学与精神病学] R589.7[医药卫生—临床医学]