卡培他滨对高表达HER-2/neu卵巢癌裸鼠的治疗作用  

Therapeutic effect of Capecitabine on ovarian cancer of nude mice in the high expression of HER-2/neu

作　　者：徐志宏[1] 刘荣凤[1] 姚铁柱[2] 史健[1] 段晓阳[1] 梁秀琴 吴小华 Xu Zhihong Liu Rongfeng Yao Tiezhu et al(Department of Oncolo- gy Department of Cardiovascular, Fourth Hospital of Hebei Medical University, Shifiazhuang 050011)

机构地区：[1]河北医科大学第四医院肿瘤内科,石家庄050011 [2]河北医科大学第四医院心内科,石家庄050011 [3]保定第七医院妇产科,保定071000 [4]白求恩国际和平医院妇产科,石家庄050000

出　　处：《现代妇产科进展》2016年第12期904-906,共3页Progress in Obstetrics and Gynecology

摘　　要：目的:探讨卡培他滨对高表达HER-2/neu卵巢癌裸鼠的治疗作用。方法:66只雌性健康裸鼠皮下接种人卵巢癌SKOV3细胞,建立试验模型。根据用药情况将裸鼠分成两组:对照组(塞来昔布灌胃治疗,33只)和观察组(塞来昔布联合卡培他滨灌胃治疗,33只)。比较两组SKOV3细胞的生长抑制率、肿瘤体积及肿瘤抑制率,同时观察两组裸鼠的p53标记指数、HER-2/neu标记指数。结果:观察组的细胞生长抑制率为(65.11±0.86)%,高于对照组(40.38±0.58)%,差异有统计学意义(P<0.01)。观察组的肿瘤抑制率高于对照组,差异有统计学意义(P<0.01)。观察组裸鼠的p53标记指数、HER-2/neu标记指数均低于对照组,差异有统计学意义(P<0.01)。结论:卡培他滨在高表达HER-2/neu卵巢癌裸鼠的治疗中作用显著,能有效抑制肿瘤细胞的生长,作用机制可能是卡培他滨能调控p53、HER-2/neu基因表达。Objective：To investigate the therapeutic effect of Capecitabine on ovarian cancer of nude mice in the high expression of HER-2/neu. Methods：66 female healthy nude mice were inoculated subcutaneously with human ovarian cancer SKOV3 cells, and the model was established. The nude mice were divided into two groups according to the use of the drug, each of which was 33. Control group：celecoxib treatment. The observation group：celecoxib com-bined with capecitabine in treatment of gastric lavage. SKOV3 cell growth inhibition rate, the tumor volume and tumor inhibition rate of the two groups were compared. The p53 markers and HER-2/neu markers were observed. Results：The inhibitory rate of cell growth in the observa-tion group （65. 11±0. 86）% higher than that of the control group（40. 38±0. 58）%,the differ-ence was statistically significant （ P〈0 . 01 ） . The tumor inhibition rate of the observation group was higher than that of the control group,the difference was statistically significant（P〈0. 01）. The p53 markers and HER-2/neu markers in the observation group were all lower than those in the control group,and the differences were statistically significant （P〈0. 01）. Conclusions：Capecitabine plays an important role in the treatment of high expression of HER-2/neu nude mice with ovarian carcinoma, and capecitabine can effectively inhibit tumor cell growth. The mechanism of capecitabine may be regulation of p53 and HER-2/neu gene expression.

关 键 词：卵巢癌 卡培他滨 高表达HER-2/neu 裸鼠 

分 类 号：R737.31[医药卫生—肿瘤]