输卵管癌复发和生存影响因素的多因素分析  

Primary fallopian tube carcinoma: multivariate analysis of factors influencing recurrence and survival

作　　者：孟祥程[1] 霍明娟 孙影[1] 刘乾[2] 程丽[1] Meng Xiangcheng Huo Mingjuan Sun Ying et al(The Cancer Affiliated Hospital of Harbin Medical University,Harbin 150040)

机构地区：[1]哈尔滨医科大学附属肿瘤医院,哈尔滨150040 [2]亳州市人民医院,亳州236800

出　　处：《现代妇产科进展》2016年第12期916-919,共4页Progress in Obstetrics and Gynecology

摘　　要：目的:总结输卵管癌的临床特征,探讨影响输卵管癌复发与生存的因素。方法:回顾分析2001年1月至2011年5月黑龙江省肿瘤医院收治的52例原发性输卵管癌患者的临床资料,采用Cox风险比例回归模型进行生存分析。结果:52例患者的复发率为59.6%(31/52),生存率为42.3%(22/52)。单因素分析显示,FIGO分期、CA125值、组织分级、残余病灶大小与输卵管癌的复发和生存预后有关。多因素分析显示,FIGO分期、CA125值、组织分级、残余病灶大小是影响输卵管癌复发的重要因素,FIGO分期、CA125值、残余病灶大小是影响患者生存预后的重要因素。结论:FIGO分期晚、术前CA125高、组织分化差、残余病灶大的患者复发的风险大;FIGO分期晚、术前CA125高、残余病灶大的患者预后差。对于有上述危险因素的患者应加强随访,及时给予干预治疗,从而提高患者术后生存期,改善患者生存质量。Objective：To summarize the clinical features of fallopian tube carcinoma and explore the factors influencing the recurrence and survival of fallopian tube carcinoma. Methods：A retrospective analysis was conducted of the 52 patients of primary fallopian tube carcinoma in Heilongjiang carcinoma hospital from Jan. 2001 to May 2011. Cox proportional hazards model was used for survival analysis. Result：The recurrence rate of the whole group was 59. 6%（31/52）,and the 5-year overall survival rate was 42. 3%（22/52）. Single-factor a-nalysis showed that FIGO stage,elevated preoperative CA125,histological grade and residual tumor diameter were associated with recurrence and prognosis. Multifactor analysis showed that FIGO stage,elevated preoperative CA125,histological grade,residual tumor diameter were asso-ciated with recurrence. Multifactor analysis showed that FIGO stage, elevated preoperative CA125,residual tumor diameter were associated with prognosis. Conclusions：Patients with late FIGO stage,high preoperative CA125,poor histological differentiation and large residual lesions have high risk for recurrence. Patients with late FIGO stage,high preoperative CA125 and large residual lesions have a poor prognosis. For patients who have the risk factors,we think intensive following-up visits and timely intervention treatment should be considered, which will help to extend the postoperative life expectancy of patients and improve patientsˊlife quality.

关 键 词：输卵管癌 复发 预后 多因素分析 

分 类 号：R737.32[医药卫生—肿瘤]