腹腔镜肝切除术与射频消融术治疗小肝细胞癌疗效及对生活质量的影响  

Clinical Efficacy and Quality of Life in Treatment of Small Hepatocellular Carcinoma:Laparoscopic Hepatectomy Versus Radiofrequency Ablation

作　　者：何若琦[1] 徐鸿涛[1] 

机构地区：[1]汉中市人民医院,陕西汉中723000

出　　处：《肿瘤学杂志》2016年第12期1048-1051,共4页Journal of Chinese Oncology

摘　　要：[目的]比较腹腔镜肝切除术与射频消融术治疗小肝细胞癌的疗效及对患者生活质量的影响。[方法]收取小肝细胞癌患者79例作为研究对象,根据术式不同将其分为腹腔镜组(41例)和射频消融组(38例),分别采用腹腔镜肝切除术与射频消融术进行治疗。比较两组患者围手术期指标(手术时间、术中出血量、输血例数及住院时间)、治疗效果、术后疼痛评分、并发症以及生活质量恢复情况。[结果]射频消融组手术时间、术中出血量、输血例数及住院时间均显著低于腹腔镜组,差异具有统计学意义(P<0.05)。腹腔镜组总缓解率(85.37%)低于射频消融组(89.47%),但差异无统计学意义(P>0.05)。射频消融组疼痛VAS评分明显低于腹腔镜组,差异有统计学意义(P<0.05)。两组并发症无统计学差异(P>0.05)。射频消融组生活质量改善率(60.52%)明显高于腹腔镜组(31.71%),差异有统计学意义(P<0.05)。[结论]采用射频消融术治疗小肝细胞癌与腹腔镜肝切除术相比具有更好的临床疗效,利于减轻疼痛并提高患者生活质量。[Objective] To compare the clinical efficacy and quality of life of patients between laparoscopic hepatectomy and radiofrequency ablation in treatment of small hepatocellular carcinoma（HCC）. [Methods] Seventy-nine patients with small HCC were treated with laparoscopic hepatectomy（n=41） or radiofrequency ablation（n=38）. The perioperative indexes（operation time,blood loss,blood transfusion cases and hospital stay）,clinical efficacy,postoperative pain score,complications and improvement of quality of life were compared beween two groups. [Results] The operation time,blood loss,blood transfusion cases and hospital stay of radiofrequency ablation group were significantly lower than those in laparoscopic group（all P〈0.05）. There were no significant difference in overall response rate between laparoscopic group（85.37%） and radiofrequency ablation group（89.47%,P〈0.05）. Pain visual analogue score（VAS） of radiofrequency ablation group was significantly lower than that of laparoscopic group（P〈0.05）. The complications of two groups had no difference（P〈0.05）. The improvement rate of quality of life in radiofrequency ablation group was 60.52%,which was significantly higher than that in laparoscopic group（31.71%,P〈 0.05）. [Conclusion] Radiofrequency ablation has more favorable clinical efficacy,less pain and better quality of life of patients than laparoscopic hepatectomy in treatment of small hepatocellular carcinoma.

关 键 词：小肝细胞癌 腹腔镜 肝切除术 射频消融 

分 类 号：R735.7[医药卫生—肿瘤]