SIRT4基因表达与骨肉瘤预后因素相关性研究  

The study on SIRT4 gene expression and prognostic factors in osteosarcoma

作　　者：石庆宇[1] 李连财[1] 麦威[1] 包俊杰[1] 宋春雨[1] 曲国蕃[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院骨外科,哈尔滨150040

出　　处：《实用肿瘤学杂志》2016年第6期502-506,共5页Practical Oncology Journal

基　　金：黑龙江省卫生计生委科研课题(2014-355)

摘　　要：目的研究信息沉默因子4(SIRT4)基因在骨肉瘤组织中的表达及其临床意义。方法本研究对106例骨肉瘤和36例配对的瘤旁正常组织进行SIRT4免疫组织化学染色,并进行结果评分,综合患者临床病理特征进行统计分析。结果相对于瘤旁正常组织,SIRT4蛋白在骨肉瘤组织中显著降低,低表达SIRT4骨肉瘤患者与较短的生存期显著相关。单变量和多变量Cox比例风险模型分析显示SIRT4表达与骨肉瘤预后生存显著相关。结论SIRT4基因可能成为判断骨肉瘤预后生存的生物学指标。Objective To explore SIRT4 gene expression in tumor tissue and investigate the clinicolpathological features in osteosarcoma.Methods In this study,SIRT4 protein expression was detected in 106 osteosarcoma tissues and 36 paired neighboring non- tumorous tissues by immunohistochemistry and determined the correlation between the SIRT4 expression and the clinicopathological features.Results SIRT4 protein was dramatically decreased in osteosarcoma cells compared with neighboring non- tumorous bone cells.The low expression of SIRT4 was notably associated with a poor overall survival and disease- free survival in osteosarcoma patients.By using univariate and multivariate analyses,we confirmed that the increased SIRT4 expression was an independent factor in predicting better prognosis for patients.Conclusion SIRT4 expression might be an independent biomarker for prognostic evaluation of osteosarcoma.

关 键 词：骨肉瘤 免疫组织化学染色 SIRT4蛋白 生存分析 

分 类 号：R738.1[医药卫生—肿瘤]