加味柴芍六君颗粒调节溃疡性结肠炎肠道微生态的作用及机制  

Effect and Mechanism of Jiawei Chaishao Liujun Granule Regulating Ulcerative Colitis Intestinal Microecology

作　　者：李哮天 李桂贤[2] 郑超伟[2] 王伟[2] 余静芳[1] 刘丹[1] 王雪[1] 蒙竹韵 

机构地区：[1]广西中医药大学研究生学院,广西南宁530000 [2]广西中医药大学第一附属医院,广西南宁530000

出　　处：《辽宁中医杂志》2016年第12期2569-2571,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81260532)

摘　　要：目的:研究加味柴芍六君颗粒调节溃疡性结肠炎患者肠道微生态的作用及机制。方法:将90例溃疡性结肠炎患者按随机数字表随机分入两组中,治疗组48例,给予加味柴芍六君颗粒口服治疗;对照组42例,给予柳氮磺胺吡啶肠溶片口服治疗。在服药前及治疗3个月后进行临床症状评分、肠镜下评分、肠道菌群测定、血清白细胞介素-10、白细胞介素-1β、肿瘤坏死因子α和干扰素γ测定。结果:加味柴芍六君颗粒治疗溃疡性结肠炎疗效显著,比柳氮磺胺吡啶肠溶片疗效更优;两组患者肠道菌群变化明显,均为乳酸菌和双歧杆菌的含量增加,肠球菌、大肠杆菌含量减少;两组患者血清白细胞介素-10、白细胞介素-1β、肿瘤坏死因子α和干扰素γ有变化,均为白细胞介素-1β、白细胞介素-10含量上升,肿瘤坏死因子α和干扰素γ含量下降。结论:加味柴芍六君颗粒能有效治疗溃疡性结肠炎,其可能的机制为调整肠道菌群及促使体内促炎因子分泌增加、抑制抑炎因子水平下降。Objective ： To study the effects of fiawei Chaishao Liujun Granule regulating the intestinal microecology of patients with ulcerative colitis and its mechanism. Methods：Ninety patients with ulcerative colitis according to the random number table were randomly divided into two groups. The treatment group （48 cases） were treated with Jiawei Chaishao Liujun Granule orally and the control group （ n = 42） were given Sulfasalazine Enteric Coated Tablets. Before and 3 months after treatment, we determined clinical symptom score, endoscopic score and intestinal flora determination and serum interleukin -10, interleukin- 1β, tumor necrosis factor alpha and interferon gamma. Results ： Jiawei Chaishao Liujun Granule in the treatment of ulcerative colitis had distinct curative effect which was better than that of Sulfasalazine Sulfasalazine Enteric Coated Tablets. Two groups intestinal bacteria group changed significantly： Lactobacillus and Bifidobacterium contents increased while enterococci and E. coli reduced. The two groups＇ serum interleukin- 10, interleukin- 1β, tumor necrosis factor alpha and interferon gamma changed ： interleukin -1β and interleukin 10 levels increased and tumor necrosis factor alpha and interferon gamma were in decline. Conclusion： Jiawei Chaishao Liujun Granule is effective in the treatment of ulcerative colitis and its possible mechanism may be adjusting the intestinal flora and promoting in vivo proinflammatory cytokine secretion and suppressing the decline of cytokine levels.

关 键 词：加味柴芍六君颗粒 溃疡性结肠炎 肠道微生态 炎性因子 

分 类 号：R574.62[医药卫生—消化系统]