中医药治疗阿尔茨海默病APP/PS1双转基因小鼠的研究进展  

Research Development of Traditional Chinese Medicine in Treatment of Double Transgenic APP/PS1 Mice of Alzheimer's Disease

作　　者：宋琳[1] 陆一婵 朴钟源[2] 邸智勇[2] 房秋菊[2] 姜卓[1] 敖丽梅[1] 姚丽芬[3] 

机构地区：[1]黑龙江中医药大学基础医学院,黑龙江哈尔滨150040 [2]黑龙江省医院,黑龙江哈尔滨150040 [3]哈尔滨医科大学第一附属医院,黑龙江哈尔滨150001

出　　处：《辽宁中医杂志》2016年第12期2679-2683,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81302904;81673860);黑龙江省自然科学基金项目(H201469);黑龙江省博士后科研项目(LBH-Z05231);黑龙江省博士后科研启动项目(LBH-Q10007)

摘　　要：中医药治疗阿尔茨海默病具有多靶点、多方式、多途径的优势。能反映AD特征的APP/PS1双转基因小鼠是一种比较理想的AD动物模型,该模型现已成功应用到中医药防治AD研究的领域。该文综述近年来中药复方及有效成分治疗阿尔茨海默病APP/PS1双转基因小鼠的实验研究。The advantages of traditional Chinese medicine in the treatment of Alzheimer＇s disease are multi -targets, multi - systems and various ways. Double transgenic APP/PS1 mice which can reflect the characteristics of AD is an ideal animal model of AD, which has been successfully applied to the field of traditional Chinese medicine AD research. This paper summarizes the research progress of Chinese herbal compound and effective components in the treatment of the double transgenic APP/PS1 mice of Alzheimer＇s disease.

关 键 词：阿尔茨海默病 APP/PS1双转基因小鼠 中医复方 中药单体 

分 类 号：R741[医药卫生—神经病学与精神病学]