黄连素的β-环糊精包合物的制备  

The Research of Berberine Inclusion by Cyclodextrin

作　　者：李家贵[1] 林艳凤[1] 黄肇宇[2] 朱万仁[1] 

机构地区：[1]玉林师范学院化学与食品学院,广西玉林537000 [2]玉林师范学院生物与制药学院,广西玉林537000

出　　处：《玉林师范学院学报》2016年第5期49-53,共5页Journal of Yulin Normal University

基　　金：玉林市科技开发项目经费支助(玉市科能11042039)

摘　　要：β-环糊精(β-CD)环的两端和外部为亲水性,而其内腔为疏水性,能与许多有机、无机和生物分子等分子形成主-客体包合物.环糊精的化学性质很稳定,一般食品中的pH不会导致环糊精的分解,环糊精溶于水后仍能保持环状结构及形成络合物的能力.β-CD作为超分子化合物主体,在生成包合物后可以改善客体分子的物理化学性质和生物活性,比如溶解度、稳定性及其生物利用度等.因此在超分子领域得到了广泛的应用.本文通过实验制备了黄连素的β-环糊精包合物.实验结果表明:黄连素用量为0.03g,β-环糊精2.0g,包合时间90 min,包合物的包合效果较好.包合物分别用紫外分光光度计、红外、粉末衍射、电子显微镜等进行测定.β -cyclodextrin （β-CD） at both ends and external to hydrophilic, internal for hydrophobic and cylinder can form host-guest inclusion compound and molecular with many organic, inorganic and biological molecules. Chemical properties of cyclodextrin is stable. General food of the pH can not lead to decomposition of cyclodextrin, and cyclodextrin can keep the ability of ringing structure and form compounds after soluble in water. β -CD, as the supramolecular compound, has a very wideapplications in the supramolecular chemistry. It can include many guest molecules with hydrophobic interaction and improve physicochemical and biological properties of guest molecules. In this paper, it use the method of orthogonal experiment to prepare the clathrate compound β-cyclodextrin-berberine. The experimental results show that： berberine dosage 0.03 g, β-CD 2.0 g, cyclodextrin inclusion time 90 rain, the effect of clathrate inclusion is better. The clathrate compound of β -cyclodextrin-berberine were characterized by US, IR, XRD, AEM.

关 键 词：Β-环糊精 黄连素 包合物 

分 类 号：O621[理学—有机化学]