原卟啉IX二钠盐的低能铁离子束辐照产物对实验性小鼠再生障碍性贫血的疗效初步研究  

Preliminary Studies on the Curative Effect on Experimental Mouse Aplastic Anemia of Radiation Products of Low-Energy Fe^+ Ion Beam Irradiated Protoporphyrin IX Disodium

作　　者：袁世斌[1] 卫增泉 李文建[1] 梁剑平[1] 高清祥[2] 傅四希 

机构地区：[1]中国科学院近代物理研究所 [2]兰州大学生命科学学院,中国甘肃兰州730000

出　　处：《激光生物学报》2002年第4期263-267,共5页Acta Laser Biology Sinica

基　　金：国家自然科学基金 (19975 0 6 0 );中科院创新基金 (CX0 10 0 0 7)资助

摘　　要：利用 110 ke V Fe+ 离子注入原卟啉 IX二钠盐薄膜 ,动物实验和细胞学观察等表明辐照混合产物对于治疗 6 0 Coγ射线所致实验性小鼠再生障碍性贫血具有一定的疗效 ,且无明显的毒副作用 。Fe + ion beams with the energy of 110 keV were implanted into films of protoporphyrin IX disodium.The results of animal experiments and cellular examinations showed that the mixed product obtained after low energy ion beam irradiation had certain curative effect on 60 Co γ ray induced experimental mouse aplastic anemia,while no obvious poisonous or side effect was discovered.Its hopeful to screen out some new drugs against aplastic anemia,or their precursors after further studies.

关 键 词：低能离子注入 辐照效应 分子改性 原卟啉 再生障碍性贫血 

分 类 号：Q691[生物学—生物物理学] R556.5[医药卫生—血液循环系统疾病]