骨髓间质干细胞减轻收缩期高血压的心肌损伤  

Bone marrow mesenchymal stem cell transplantation alleviates myocardial injury due to systolic hypertension

作　　者：王勇[1] 张亚光 Wang Yong Zhang Ya-guang(Henan Provincial People＇s Hospital, Zhengzhou 450000, Henan Province, China Henan Medical College, Zhengzhou 450000, Henan Province, China)

机构地区：[1]河南省人民医院,河南省郑州市450000 [2]河南省医学高等专科学校,河南省郑州市450001

出　　处：《中国组织工程研究》2016年第50期7518-7523,共6页Chinese Journal of Tissue Engineering Research

基　　金：河南省科技攻关计划项目(132300410424)~~

摘　　要：背景:研究发现骨髓间质干细胞可以用于多种损伤性疾病的治疗,但关于骨髓间质干细胞治疗收缩期高血压的研究不多。目的:探讨骨髓间质干细胞对收缩期高血压大鼠的治疗作用。方法:24只大鼠等分为对照组、模型组和骨髓间质干细胞移植组。模型组和骨髓间质干细胞移植组采用维生素K和华法林纳制备单纯收缩期高血压大鼠模型。骨髓间质干细胞移植组大鼠左心室注射骨髓间质干细胞,模型组和对照组注射生理盐水。结果与结论:与模型组相比,骨髓间质干细胞移植组大鼠的左心室质量指数降低,心脏组织中Ⅰ型胶原容积分数、胶原容积分数和血管周围胶原容积分数上升,但舒张末期容积/体质量比没有明显改变。表明骨髓间质干细胞移植治疗收缩期高血压大鼠能够改善大鼠的心肌肥厚状况,改善大鼠的心脏纤维化程度。BACKGROUND：Mesenchymal stem cel s can be used to treat a variety of injuries, but little is known about their effect on systolic hypertension. OBJECTIVE：To study the therapeutic effect of bone marrow mesenchymal stem cel s on systolic hypertension rats. METHODS：Twenty-four rats were randomized equal y into control, model and cel transplantation groups. A rat model of systolic hypertension was made by injection of vitamin K and warfarin sodium in the model and cel transplantation groups. Rats in the cel transplantation group were given injection of bone marrow mesenchymal stem cel s into the left ventricle, while those in the other two groups given normal saline. RESULTS AND CONCLUSION：Compared with the model group, bone marrow mesenchymal stem cel s could reduce left ventricular mass index, increase cardiac tissue type I col agen volume fraction, col agen volume fraction and perivascular col agen volume fraction, but the ratio of end-diastolic volume/body weight did not change significantly. These findings indicate that bone marrow mesenchymal stem cel transplantation can reduce myocardial hypertrophy and cardiac fibrosis in systolic hypertension rats.

关 键 词：干细胞 移植 骨髓间质干细胞 收缩期高血压 细胞移植 心肌损伤 心肌肥厚 纤维化 

分 类 号：R394.2[医药卫生—医学遗传学]