白细胞介素2联合顺铂治疗恶性胸腔积液有效性及安全性的Meta分析  

Effectiveness and safety of interleukin-2 plus cisplatin for treating malignant pleural effusion:a meta analysis

作　　者：孙永苹[1,2] 汪成琼 陈玲[3] 李娜娜[3] 姚新生[4] 肖政[1,3] 

机构地区：[1]遵义医学院附属医院遵义医学院循证医学中心/循证医学教育部网上合作研究中心遵义医学院分中心,贵州遵义563003 [2]遵义医学院珠海校区循证医学教研组,广东珠海519100 [3]遵义医学院附属医院呼吸内科/遵义医学院附属医院重大传染性疾病循证与转化研究中心,贵州遵义563003 [4]遵义医学院免疫教研室,贵州遵义563003

出　　处：《重庆医学》2017年第1期84-89,93,共7页Chongqing medicine

基　　金：遵义医学院博士启动基金(F-617);贵州省哲学社会科学规划基金(14GZYB58);贵州省第五批科技创新人才团队项目[黔科合(2012)4011]

摘　　要：目的系统评价白细胞介素2联合顺铂治疗恶性胸腔积液的有效性及安全性,为临床治疗策略提供依据。方法系统检索中国生物医学文献数据库(BM)、中国学术期刊网络出版总库(CNKI)、维普(VIP)、万方、ISI、Pubmed、Embase及Cochrane library临床试验注册数据库,采用Cochrane协作网RCT质量评价标准评价纳入研究质量,Meta分析提取数据。结果(1)纳入34个RCT,2 037例恶性胸腔积液患者,纳入研究质量一般;(2)与单独使用顺铂比较,Meta分析合并相对危险度(RR)值:ORR[RR=1.45,95%CI(1.36~1.54),P<0.01]及发热[RR=2.37,95%CI(1.53~3.66),P<0.05]比较差异有统计学意义;白细胞减少症[RR=0.81,95%CI(0.61~1.07),P=0.14];骨髓抑制[RR=0.83,95%CI(0.62~1.11),P=0.21]及胸痛[RR=1.04,95%CI(0.84~1.29),P=0.69]在两组间差异无统计学意义。结论本研究表明IL-2联合顺铂能显著改善恶性胸腔积液患者近期疗效,但存发热等不良反应,纳入研究质量一般。Objective To systematically evaluate the effectiveness and safety of interleukin-2 plus cisplatin for treating malignant pleural effusion（MPE） to provide a basis for clinical treatment strategy. Methods CBM, CNKI, VIP, Wanfang, Pubmed, Embase,Cochrane library clinical trial registration database were systematically retrieved. The randomized controlled trial（RCT） quality assessment criteria of Cochrane collaboration network was adopted for including the study quality. The data were extracted by meta analysis. Results （1） Thirty-four RCT involving 2 037 MPE patients were included,the quality of included RCT was ordinary;（2）compared with simple cisplatin, the merged RR values and their 95% CI of meta-analysis for ORR, fever, were 1. 45 （1.36-1.54） ,2.37（1.53-3.66）,respectively,the differences between the two groups were statistically significant（P〈0.05）. The merged RR values and their 95%CI of meta-analysis for leukopenia, myelosuppression and thoracalgia were 0. 81（0. 61- 1.07）, 0.83 （0.62 - 1.11 ） and 1.04 （0.84 - 1.29） respectively, the differences between two groups were not statistically significant （P〈0.05）. Conclusion This study indicates that IL-2 plus cisplatin can significantly improve the clinical curative effect in the patients with MPE,but has the adverse reactions of fever,etc, and the quality of included RCT is general.

关 键 词：白细胞介素2 顺铂 胸腔积液 恶性 META分析 

分 类 号：R730.5[医药卫生—肿瘤]