证候表型组学的理论问题与应用构想  

Theoretical Problems and Application Conception of Syndrome Phenomics

作　　者：魏盛[1,2] 孙鹏[1,2] 王杰琼[1] 宋春红[1] 陈刚[3] 陈家旭[4] 乔明琦[1] 

机构地区：[1]山东中医药大学中医药经典理论教育部重点实验室 [2]山东中医药大学脑行为分析实验室 [3]南京中医药大学中医脑病研究重点实验室 [4]北京中医药大学基础医学院

出　　处：《中医杂志》2017年第1期6-10,共5页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81573854)

摘　　要：动物行为分析是判定模型动物证候归属并理解中医证本质的核心关键技术。通过对现代动物行为学思路和方法进展的梳理与总结,提出证候/病证结合动物模型行为评价中的证候表型组学概念。通过分析这一学科领域中的若干关键理论问题,提出证候表型组学技术应用于中医药领域的若干构想,包括基因操纵技术的联合应用有望带来学科领域的大发展、长时程行为监控笼具是未来动物行为分析的可能趋势、对动物模型行为的结构分析有助于更好地理解证候表征的复杂内涵,为解决动物模型的证候属性判别、揭示中医证候的复杂内涵提供思路与方法。Animal behavior analysis is the key important technology to decide model animal syndrome and understand the essence of Chinese medicine ＂syndrome＂. By summarizing the thinking and method development of modern animal ethology,the authors put forward the concept of syndrome phenomics in syndrome / disease-syndrome combination animal model behavior evaluation. By analyzing several important theoretical problems in this subject field,the authors point out several assumptions of syndrome phenomics technology applied to the field of Chinese medicine,including possible great development of subject field brought by joint application of gene manipulation techniques,as well as long term behavior monitoring cage which might be the possible trend of animal behavior analysis in the future.This article provides ideas and methods for solving the syndrome attribute decision of animal model and revealing the complex connotation of Chinese medicine syndrome.

关 键 词：证候表型组学 动物模型 行为分析 行为表征技术 中医证型 

分 类 号：R228[医药卫生—中医基础理论]