子宫内膜癌中ER、PR、Ki67的表达及其临床意义  

Expressions and clinical significances of ER、PR、Ki-67 in endometrial carcinoma

作　　者：吐尔逊阿衣.买买提明 马春华[1,2] 王琳[1] Tuerxunayi. Maimaitiming MA Chunhua WANG Lin(1.Department of gynecology, People＇s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang, Urumqi, 830000 postgraduate school of Xinjiang Medical University, Xinjiang, Ummqi, 830001)

机构地区：[1]新疆维吾尔自治区人民医院妇科,乌鲁木齐830000 [2]新疆医科大学研究生院,乌鲁木齐830001

出　　处：《新疆医学》2016年第11期1384-1386,共3页Xinjiang Medical Journal

摘　　要：目的联合检测子宫内膜癌组织中雌激素受体ER、孕激素受体PR,细胞增殖核抗原Ki-67的表达水平,探讨相关临床意义。方法应用免疫组化对75例子宫内膜癌组织进行ER、PR、Ki-67检测,结合临床及病理指标进行分析。结果ER、PR、Ki-67在75例子宫内膜癌的阳性表达率分别为78.3%、80%及80%,ER、PR、Ki-67在子宫内膜癌的阳性表达率与手术病理分期,组织病理学分级有关,Ki-67与肌层浸润有关,ER、PR与病理组织类型有关,差异有显著性(P<0.05)。结论联合检测ER、PR、Ki-67的表达有助于判断子宫内膜癌的生物学行为及预后。Objective To detect the expression levels of endometrium estrogen receptors（ER）, progesterone receptor（PR） and Ki-67 proliferating cell nuclear antigen in carcinoma and discuss their chnieal significance. Methods The expression of ER, PR and Ki-67 at 75 eases of endometrial Carcinoma were determined through immunohistoehemistry assay, and data were analyzed and combined with clinical and pathological indicators. Results Positive expression rate of ER, and PR, and Ki-67 in 75 cases were 78.3%, 80% and 80%, respectively. Their expression was related with operation-pathologic stage and histopathological grade. Ki-67 was related with myometrial invasion. ER, and PR was connected with histopathologieal type. All differences were significant （P〈 0.05）. Conclusion detecting ER, PR expression and Ki-67 can be helpful to determine the biological behavior of endometrial carcinoma and its prognosis.

关 键 词：子宫内膜肿瘤 雌激素受体 孕激素受体 细胞增殖核抗原Ki-67免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]