对比两种不同药物治疗老年原发性三叉神经痛患者的疗效和对睡眠质量的影响  

Comparison of curative effects by two different drugs in the treatment of senile primary trigeminal neuralgia patients and their influence on quality of sleep

作　　者：杨志春[1] 

机构地区：[1]建昌县人民医院内一科,125300

出　　处：《中国实用医药》2016年第32期131-133,共3页China Practical Medicine

摘　　要：目的观察拉莫三嗪与卡马西平治疗老年原发性三叉神经痛患者临床疗效以及对睡眠质量的影响。方法 72例原发性老年三叉神经痛患者,根据随机数字表法分为实验组和对照组,每组36例。实验组口服拉莫三嗪,对照组口服卡马西平。观察两组患者的临床治疗疗效、不良反应发生率以及睡眠质量评分。结果实验组显效23例、有效10例、无效3例;对照组显效14例、有效10例、无效12例,实验组的治疗总有效率为91.67%,显著高于对照组的66.67%,差异具有统计学意义(χ2=6.821,P<0.05)。实验组患者治疗2个月后的睡眠质量总评分为(13.45±0.36)分,低于对照组的(16.64±0.42)分,差异具有统计学意义(t=-34.600,P<0.01)。实验组不良反应发生率为16.67%,对照组为19.44%,两组比较差异无统计学意义(χ2=0.094,P=0.759>0.05)。上述不良反应均未做特殊处理,后患者自行缓解。结论拉莫三嗪治疗老年原发性三叉神经痛近期疗效显著,安全性高,且有利于老年患者的睡眠,值得临床推广。Objective To observe clinical effects by lamotrigine and carbamazepine in the treatment of senile primary trigeminal neuralgia patients and their influence on quality of sleep. Methods A total of 72 senile primary trigeminal neuralgia patients were divided by random number table into experimental group and control group, with 36 cases in each group. The experimental group received oral administration of lamotrigine, and the control group received carbamazepine instead. Observation was made on clinical effect, incidence of adverse reactions and quality of sleep score in both groups. Results The experimental group had 23 excellent cases, 10 effective cases, and 3 ineffective cases, and the control group had 14 excellent cases, 10 effective cases, and 12 ineffective cases. The experimental group had much higher total effective rate as 91.67% than 66.67% in the control group, and the difference had statistical significance （X2=6.821, P〈0.05）. Thf experimental group had total quality of sleep score after 2 months of treatment as （13.45 ± 0.36） points, which was lower than （16.64 ± 0.42） points in the control group, and the difference had statistical significance （t=-34.600, P〈0.01）. The experimental group had incidence of adverse reactions as 16.67%, which was 19.44% in the control group, and there was no statistically significant difference between the two groups （X 2=0.094, P=0.759〉0.05）. All mentioned adverse reactions relieved without specific treatment. Conclusion Lamotrigine shows excellent sh0rt-term effect and high safety in treating senile primary trigeminal neuralgia, and it is beneficial for sleep in senile patients. It is worth clinical promoting.

关 键 词：原发性三叉神经痛 卡马西平 拉莫三嗪 疼痛 睡眠质量 

分 类 号：R745.11[医药卫生—神经病学与精神病学]