重复经颅磁刺激治疗对孤独谱系障碍患者事件相关电位的影响  

The alteration of event-related potential after repetitive transcranial magnetic stimulation treatment in children with autism spectrum disorder

作　　者：柯晓殷 张英[1] 寇聪[1] 齐云柯 肖舟[1] 卢建平[1] 

机构地区：[1]深圳市康宁医院,深圳大学精神卫生学院,深圳518020

出　　处：《国际精神病学杂志》2016年第6期978-980,988,共4页Journal Of International Psychiatry

基　　金：深圳市科技创新委员会资助项目(编号:JCYJ20140415092628039)(编号:JCYJ20160429185235132)(编号:JCYJ20160429185854999);深圳市卫生计生系统科研项目(编号:201402093);深圳市脑神经发育障碍康复技术工程实验室(编号:深发改[2015]163号)

摘　　要：目的探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,r TMS)治疗对孤独谱系障碍(autism spectrum disorder,ASD)患者事件相关电位(event-related potential,ERP)的影响。方法 21例年龄为(7.91±1.55)岁的ASD患者入组后接受r TMS治疗和康复训练,治疗前及治疗12周进行ERP测试,并完成心理教育评定量表中文修订版(Chinese version of psycho-education profilerevised,C-PEP)评估。结果 ASD患者在治疗后P300、N400潜伏期缩短、波幅增高(P<0.05),与治疗前相比较,C-PEP总分和各分量表分的提高有统计学意义(P<0.05);ASD患者ERP变化与C-PEP总分、口语认知分、认知表现分的变化未发现相关(P>0.05)。结论 r TMS联合康复训练能有效改善ASD患者ERP表现。Objective To investigate the effect of rTMS on the ERP in children with ASD. Methods 21 ASD children were enrolled. The average age was （7.91 ± 1.55 ） years. All the participants received rTMS and rehabilitation training. ERP and C-PEP was tested at the base-line and 12 weeks after treatment. Results After rTMS treatment and rehabilitation training, latencies and amplitudes of P300 and N400 improved significantly （P 〈 0.05 ）, as well as total and sub-scales scores of C-PEP （ P〈0.05 ） . Alteration of P300 and N400 indices were not correlated with changes of C-PEP total score, verbal cognition score and cognitive performance score （ P 〉 0.05 ） . Conclusion The rTMS and rehabilitation training could effectively improve the ERP performance in patients with ASD.

关 键 词：孤独谱系障碍 重复经颅磁刺激 事件相关电位 

分 类 号：R749.94[医药卫生—神经病学与精神病学]