围绝经期妇女罹患抑郁症的危险因素分析  

Risk factors study of perimenopausal depression

作　　者：何伟健[1] 李慧[1] 阮颖清 李少梅 HE Wei-jian LI Hui RUAN Ying-qing LI Shao-mei(Obstetrics and Gynecology Department, Guangdong Women and Children Hospital, Guangzhou 511400, China)

机构地区：[1]广东省妇幼保健院,511400 [2]广州市番禺区何贤纪念医院 [3]广州市番禺区岐山医院

出　　处：《临床精神医学杂志》2016年第6期410-412,共3页Journal of Clinical Psychiatry

摘　　要：目的:探讨围绝经期妇女抑郁症的危险因素。方法:80例确诊为抑郁症的围绝经期女性患者(抑郁症组)和120例非抑郁症的围绝经期女性患者(对照组)进行艾森克人格量表(EPQ)、生活事件量表(LES)、社会支持量表(SSRS)的自评,同时检测两组血雌二醇激素(E2)及促卵泡刺激素(FSH)水平并进行比较。结果:抑郁症组血E2水平(t=-8.17,P=0.000)及SSRS主观支持得分(t=-3.44,P=0.001)低于对照组;血FSH水平(t=13.45,P=0.000)、LES总事件刺激分(t=5.42,P=0.00)、负性事件刺激分(t=7.97,P=0.000)、EPQ-N(神经质)分(t=8.32,P=0.000)、EPQ-P(精神质)分(t=3.84,P=0.00)高于对照组。多因素非条件Logistic回归提示,血E2、FSH水平、LES负性事件评分、EPQ-N评分的回归系数β分别为-0.117、1.116、0.372、0.290(P<0.01或P<0.001)。结论:血E2、FSH水平、社会心理因素、负性事件刺激及神经质人格是围绝经期妇女罹患抑郁症的危险因素。Objective：To explore the risk factors of perimenopausal depression. Method：The study group（80 cases）with perimenopausal depreesion and the control group（120 cases）without perimenopausal depression subjects received peripheral blood tests including estradiol（E2）and follicle-stimulating hormone （FSH）. Eysenck personality infentory（ EPQ）,life event scale（ LES）and social support revalued scale （SSRS）were administered to all subjects. Results：The study group showed lower concentration of E2（t =- 8. 17,P = 0. 000）and SSRS（t = - 3. 44,P = 0. 001）than the control group,while the study group showed higher FSH（t = 13. 45,P = 0. 000）,LES total score（ t = 5. 42,P = 0. 00 ）,LES negative event score （t = 7. 97,P = 0. 000）,EPQ neurotic score （ t = 8. 32,P = 0. 000 ） and EPQ psychotic score （t = 3. 84,P = 0. 00）. Logistic regression analysis showed the coefficient β of estradiol,E2 level,blood FSH lev-el,negative event（LES）and nervousness（EPQ）were - 0. 117,1. 116,0. 372,0. 290 respectively（ P 〈 0. 01 or P 〈 0. 001）. Conclusion：The risk factors of perimenopausal depression are the negative life event,nervous personality,lower concentration of estradiol and higher concentration offollicle-stimulating hormone.

关 键 词：抑郁症 围绝经期 危险因素 

分 类 号：R749.4[医药卫生—神经病学与精神病学]