中老年人群非酒精性脂肪性肝病和幽门螺杆菌感染的关系  

Mucosal healing quality of hydrotalcite combined with esomeprazole in gastric ulcer

作　　者：陈长喜[1] 郭传勇[2] 毛玉山[3] 朱忠伟 杜娟 陈晓菲 余荣 王汇 

机构地区：[1]苏州大学附属第一医院消化内科,215006 [2]同济大学附属第十人民医院消化内科 [3]宁波大学附属医院内分泌科 [4]宁波市镇海区炼化医院内科

出　　处：《中华消化杂志》2016年第12期839-842,共4页Chinese Journal of Digestion

基　　金：宁波市科技计划项目（2013C50044、2011C50021）;宁波市镇海区社会发展科技项目（2013S1002）;宁波市镇海区医学科技计划项目（2014020）

摘　　要：非酒精性脂肪性肝病（non-alcoholicfattyliverdisease，NAFLD）是指除外乙醇和其他明确的肝损伤因素，以弥漫性肝细胞大泡性脂肪变为病理特征的临床综合征。近年来，随着经济水平的提高和生活方式的改变，NAFLD的发病率呈明显上升趋势，普通人群中NAFLD的患病率高达20％～60％，已成为一种全球性疾病，严重威胁人们健康。Objective To explore the mucosal healing quality of hydrotalcite combined with esomeprazole in gastric ulcer.Methods Forty-two patients visiting from June 2014 to December 2015 and diagnosed with gastric ulcer were selected and divided into combination therapy group and single therapy group with 21 patients in each group. The patients of combination therapy group received esomeprazole combined with hydrotalcite, and the patients of single therapy group received esomeprazole alone. The total therapeutic course was eight weeks. At the same period, 21 health check-up participants were enrolled as normal control group. The healing of gastric ulcer was observed under white light endoscopy. The morphological changes of gastric pits and microvessel of mucosal at peripheral mucosa around ulcer and normal gastric mucosal were observed under narrow band imaging magnifying endoscopy. The gastric mucosa tissues of the two groups before and after treatment, and normal gastric mucosa of healthy control group were taken. The amount of deposition and composition of collagen fibers, the expression level of factor Ⅷ, the level of transforming growth factor （TGF）-beta1 and the content of hydroxyproline were analyzed by Masson, immunofluorescent and immunohistochemistry staining as well as enzyme linked immunosorbent assay. Chi square test, one-way analysis of variance （ANOVA）, least significant difference （LSD） method, Dunnett＇s T3 and Kruskal-Wallis test and other method were used for comparison.Results After treatment, 18 patients of combination therapy group （21 patients） had regular microvessel nets （85.7%）, which was significantly more than those of single therapy group （12 cases, 57.1%） and healthy control group （10 cases, 47.6%）, and the differences were statistically significant （χ2 =4.200, P=0.040）. In the comparison of maturity of regenerative mucosa between combination therapy group and single therapy group after treatment, the ration between collagen type Ⅰ and Ⅱ, deposition of c

关 键 词：非酒精性脂肪性肝病 幽门螺杆菌感染 中老年人群 NAFLD 临床综合征 损伤因素 病理特征 生活方式 

分 类 号：R575.5[医药卫生—消化系统]