米酒对瓜蒌薤白中3,29-二苯甲酰基栝楼仁三醇在人肠道菌群降解影响的研究  

Effect of Rice Wine on Degradation of 3,29-Dibenzoyl Karounitriol in Gualou-Xiebai in Human Intestinal Flora

作　　者：邹纯才[1] 李玉龙[1] 鄢海燕[1] 宗倩妮 张敏杰[1] 

机构地区：[1]皖南医学院药学院,安徽芜湖241002

出　　处：《中国药学杂志》2017年第1期53-56,共4页Chinese Pharmaceutical Journal

基　　金：安徽高校省级自然科学研究重大项目(KJ2015ZD41;KJ2016SD60);安徽省科技攻关项目(12010402089);国家大学生创新创业训练计划项目(201510368018)

摘　　要：目的研究米酒对瓜蒌薤白中主要活性成分3,29-二苯甲酰基栝楼仁三醇在人肠道菌群中代谢的影响,从代谢角度探讨瓜蒌薤白白酒汤的科学内涵。方法通过肠道菌群试验比较不同时间点瓜蒌薤白米酒溶液和水溶液中3,29-二苯甲酰基栝楼仁三醇的代谢率。结果与瓜蒌薤白水溶液组相比,瓜蒌薤白米酒溶液组中3,29-二苯甲酰基栝楼仁三醇的代谢率明显降低(P<0.05)。结论米酒可抑制瓜蒌薤白中3,29-二苯甲酰基栝楼仁三醇的代谢。OBJECTIVE To study the effects of rice wine on the metabolism of 3,29- dibenzoyl karounitriol as the main active component in Gualou-Xiebai in human intestinal flora, exploring the scientific connotation of Gualou-XiebaiBaijiu Decoction from the angle of metabolism. METHODS The metabolic rate of 3,29-dibenzoyl karounitriol in Gualou-Xiebai rice wine solution and aqueous solution at different time points were compared, respectively, by intestinal flora experiments. RESULTS Compared to Gualou-Xiebaiaqueous solution group,the metabolic rate of 3,29-dibenzoyl karounitriol in Gualou-Xiebai rice wine solution group decreased significantly （P 〈 0. 05 ）. CONCLUSION Rice wine as cites drug can inhibit the metabolism of 3,29- dibenzoyl karounitriol in Gualou-Xiebai.

关 键 词：引药 米酒 肠道菌群 

分 类 号：R969.1[医药卫生—药理学]