泽泻泄浊颗粒配合穴位贴敷治疗非酒精性脂肪肝的临床观察  

Clinical observation on treating NAFLD with the Zexie Xiezhuo pellets plus point-application

作　　者：孙晓娜[1] 于悦[1] 许向前[1] 聂山文[1] 张玉峰[1] 余金钟[1] 

机构地区：[1]河南省中医院,河南郑州450000

出　　处：《中医临床研究》2016年第35期1-4,共4页Clinical Journal Of Chinese Medicine

基　　金：河南省基础与前沿技术研究计划项目;项目编号为132300410018

摘　　要：目的:观察泽泻泄浊颗粒配合穴位贴敷治疗非酒精性脂肪肝的临床疗效。方法:选取100例非酒精性脂肪肝患者,随机分为观察组与对照组,每组50例。观察组48例给予泽泻泄浊颗粒配合穴位贴敷治疗,对照组46例给予阿托伐他汀片口服,疗程为1个月。观察两组临床疗效、证候评分、血脂、肝功能和肝硬度值的变化情况。结果:(1)观察组总有效率为95.83%,对照组为78.26%,组间比较差异有统计学意义(P<0.05)。(2)治疗后两组证候评分均较治疗前显著降低(P<0.05),且观察组低于对照组(P<0.05)。(3)两组血清TC、TG、HDL-C、LDL-C水平均较治疗前明显改善(P<0.05),且对照组低于观察组,具有显著差异(P<0.05)。治疗前后,两组AST、ALT均有所下降,组内比较差异有统计学意义(P<0.05)。与对照组治疗后相比,观察组ALT、AST有所下降(P<0.05)。结论:泽泻泄浊颗粒配合穴位贴敷能减轻非酒精性脂肪肝的严重程度,改善脂质代谢,保护肝功能,值得进一步研究。Objective： To observe efficacy of the Zexie Xiezhuo pellets and point-application on nonalcoholic fatty liver disease. Methods： 100 cases were randomly divided into the control group and observation group, 50 cases in each group. The observation group was treated with the Zexie Xiezhuo pellets plus point-application; the control group was given atorvastatin, for 1 month. The efficacy, symptom score, blood fat, liver function and liver stiffness were observed. Results： The total efficiency was 95.83% in the observation group, and 78.26% in the control group, with a statistically significant difference （P〈0.05）. The symptom scores were significantly deduced （P〈0.05）; and that was lower in the observation group （P〈0.05）. The serum TC, TG, HDL-C, LDL-C levels in groups were significantly improved （P〈0.05）; and those were better in the observation group. AST, ALT in two groups were reduced （P〈0.05）; and those were lower in the observation group （P〈0.05）. Conclusion： The Zexie Xiezhuo pellets plus point-application on NAFLD can reduce severity, improve lipid metabolism, and is worth promoting.

关 键 词：非酒精性脂肪肝 泽泻泄浊颗粒 血脂 肝功能 穴位贴敷 

分 类 号：R575.5[医药卫生—消化系统]