四联疗法对复发性幽门螺旋杆菌阳性胃溃疡的疗效及相关指标变化  

Quadruple Therapy for Recurrent Helicobacter Pylori Positive Peptic Ulcer the Curative Effect of Change and the Related Indicators

作　　者：高阳[1] 白艳红 

机构地区：[1]菏泽市传染病医院,山东菏泽274000 [2]菏泽市荣军医院

出　　处：《菏泽医学专科学校学报》2016年第4期28-32,共5页Journal of Heze Medical College

摘　　要：目的探讨四联疗法治疗复发性幽门螺杆菌(Hp)阳性胃溃疡的疗效与相关指标的变化情况。方法复发性幽门螺杆菌阳性胃溃疡患者200例,随机分为两组,各100例。对照组采用胶体果胶铋、阿莫西林、克拉霉素治疗。观察组在上述基础上加用雷贝拉唑治疗,6周后检测幽门螺杆菌。应用SPSS软件,所获数据采用方差分析、t检验和2检验。结果两组治疗后疗效、黏膜炎症阳性率及Hp检测的比较:疗效对照组显效54例,有效19例,有效率73.00%。观察组显效77例,有效10例,有效率87.00%。两组比较,P<0.05。观察组黏膜炎症阳性51例,对照组26例,两组比较,P<0.005。观察组Hp检测阳性31例,对照组16例,两组比较,P<0.05。疗效、黏膜炎症阳性率及Hp检测均有显著性差异。治疗前HCY、SOD、GSH-Px及MDA两组比较,P均>0.05。治疗前后HCY、SOD、GSH-Px及MDA同组比较,对照组P均<0.0005;观察组P均<0.0005。治疗后HCY、SOD、GSH-Px及MDA两组比较,P均<0.0005。治疗前ALT、AST、TG、TC、HDL及LCL两组比较,P均>0.05。治疗前后ALT、AST、TG、TC、HDL及LCL同组比较,对照组ALT、AST、TG,P均>0.05;TC、HDL及LCL,P均<0.001。观察组ALT、AST、TG,P均<0.05;TC、HDL及LC,P均<0.0005。治疗后ALT、AST、TG、TC、HDL及LCL两组比较,治疗后AST、TG、TC两组比较,P均>0.05;HDL两组比较,P<0.005;ALT及LCL两组比较,P<0.0005。治疗前两组比较,全血黏度(低切)、全血黏度(高切)、红细胞压积比较,P均>0.05;血浆度和聚集指数,P均<0.05。治疗前后同组比较,对照组血浆黏度,P>0.05;全血黏度(低切)、全血黏度(高切)、红细胞压积及聚集指数,P均<0.0001。治疗后两组全血黏度(低切)、全血黏度(高切)、红细胞压积、血浆度及聚集指数比较,P均<0.0005。不良反应观察组出现6例;对照组出现5例,两组比较,P<0.005。结论雷贝拉唑为主的四联疗法治疗复发性幽门螺杆菌阳性胃溃疡具有良好的疗效,提高了Hp根除率Objective To study the quadruple therapy for recurrent the curative effect of helicobacter pylori positive peptic ulcer and the change of related indicators. Methods 200 patients with recurrent helicobacter pylori positive peptic ulcer were randomly divided into two groups, 100 cases each. The control group using colloidal bismuth pectin, amoxicillin and clarithromycin treatment. Observation group based on the above treatment with ray azole Bella, six weeks after detec- tion of helicobacter pylori. The application of SPSS software, the data obtained using analysis of variance, t test and x^2 test. Results Two groups after treatment efficacy, mucosal inflammation, positive rate and the Hp testing compari son： cura rive effect of the control group 54 cases were markedly effective, efficient （19 cases）, effective rate was 73.00%. 10 cases of observation group 77 cases were markedly effective, effective, efficient 87.00%. Two groups of comparisons, P 〈 6.125）. Observe positive 51 cases of mucous membrane inflammation, and the control group 26 cases, two groups of com- parisons, P〈0.005. Detection of HP observation group Yang 31 cases, control group 16 cases, two groups of comparisons, P〈0.05. Curative effect, mucosal inflammation, HP positive rate and detection has significant difference. Before treatment of HCY, SOD, gsh-px and MDA in the two groups compare, P〉0.05. Before and after treatment of HCY, SOD, gsh-px and MDA compared group, control group, P〈0.0005. Observation group, P 〈 0.0005. After treatment of HCY, SOD, gsh- px and MDA in the two groups,P〈0.0005. Before treatment of ALT, AST, TG, TC, HDL and LCL two groups of compari- son, P〉0.05. Before and after treatment of ALT, AST, TG, TC, HDL and LCL group, control group ALT, AST, TG, P〉 0.05, TC, HDL and LCL, P〈0.001. Observation group of ALT, AST, TG, P〈0.05; TC, HDL and LC , P〈0.0005. After treatment of ALT, AST, TG, TC, HDL and LCL comparison, the two groups after treatment the AST, TG, TC two groups of comparisons, P〉0.05.

关 键 词：雷贝拉唑/治疗应用 四联疗法 幽门螺杆菌 胃溃疡/治疗 超氧化物歧化酶活性 谷胱甘肽过氧化物酶活性 丙二醛 同型半胱氨酸 血脂 血流变学 

分 类 号：R573.1[医药卫生—消化系统]