MicroRNA-124抑制实验性自身免疫性脑脊髓炎  

The Suppression of MicroRNA-124 in EAE

作　　者：邱旸[1] 渠滕 张庆[1] 崔朝杰[1] 赵文博[2] 

机构地区：[1]山东大学附属省立医院:检验医学部,山东济南250021 [2]山东大学附属省立医院:血液科,山东济南250021

出　　处：《检验医学与临床》2016年第A02期32-33,共2页Laboratory Medicine and Clinic

基　　金：山东省医药卫生科技发展计划项目（2011QZ016）.

摘　　要：目的Micro—RNAs可以调节很多生理功能，包括免疫系统中的细胞分化和活化。MicroRNA-124在中枢神经系统小胶质细胞中特异表达，本文检测MicroRNA-124对实验性自身免疫性脑脊髓炎的作用。方法本文通过给小鼠的实验性自身免疫性脑脊髓炎模型评分。结果发现静脉注射miR-124可以完全的阻止病症发展过程。结论这些发现明确了miR-124可以作为单核细胞和巨噬细胞活化中的未知调控者，对实验性自身免疫性脑脊髓炎模型的作用。Objective MicroRNAs are a class of regulatory molecules related to many immune system physiological processes, including differentiation and activation. Brain-specific miR-124 is expressed in microglia. Then, we examined the effect of microR- NA-124 on EAE. Methods Results We found that peripheral administration of miR-124 in EAE marked suppression of disease. Conclusion These findings identify miR-124 both as a key regulator of microglia quiescence in EAE and as a previously unknown modulator of monocyte and macrophage activation.

关 键 词：microRNA-124 实验性自身免疫性脑脊髓炎 抑制 

分 类 号：R744.3[医药卫生—神经病学与精神病学]