艾司西酞普兰治疗老年性抑郁症的疗效与安全性研究  

Efficacy and safety of escitalopram in the treatment of senile depression

作　　者：张梦欣 

机构地区：[1]辽宁省丹东市第一社会福利院,118000

出　　处：《临床合理用药杂志》2017年第2期3-4,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察艾司西酞普兰治疗老年性抑郁症的疗效与安全性。方法选取医院收治的81例老年性抑郁症患者作为研究对象,根据治疗方法不同分为对照组(40例),给予帕罗西汀治疗;观察组(41例),给予艾司西酞普兰治疗)。观察比较2组患者的临床疗效、HAMD评分及不良反应发生情况。结果观察组治疗总有效率为95.1%,高于对照组的80.0%(P<0.05);治疗后,观察组HAMD评分低于对照组(P<0.05或P<0.01);观察组不良反应发生率为7.3%,低于对照组的27.5%(P<0.05)。结论老年性抑郁症患者采用艾司西酞普兰治疗,可明显提高临床疗效,减轻抑郁程度,减少不良反应,值得临床推广应用。Objective To explore efficacy and safety of escitalopram in the treatment of senile depression. Methods 81 cases of patients with senile depression were selected as the research object. According to different therapeutic methods, they were divided into the control group （n = 40,give paroxetine treatment） and the observation group （n = 41, give escitalopram citalopram for treatment）. The clinical efficacy, HAMD score and adverse reactions were observed and compared between the 2 groups. Results The total effective rate was 95.1% , which was higher than 80.0% of the control group （ P 〈 0.05 ） ; After treatment, the HAMD scores of the observation group was significantly lower than the control group patients （ P 〈 0.05 or P 〈0.01 ） ;The incidence of adverse reactions of the observation group was 7.3% ,and it was lower the 27.5% of the control group （P 〈 0.05）. Conclusion For patients with senile depression, escitalopram citalopram can significantly improve the clinical efficacy, reduce the degree of depression, reduce adverse reactions, which is worthy of clinical application.

关 键 词：抑郁症 老年人 艾司西酞普兰 临床疗效 安全性 

分 类 号：R749.4[医药卫生—神经病学与精神病学]