不同手术方式治疗翼状胬肉的临床效果对比  

Clinical effect of different operation methods in the treatment of pterygium

作　　者：袁江峰[1,2] 雷岳山[1,2] 

机构地区：[1]武汉大学基础医学院,武汉430071 [2]湖北省阳新县人民医院眼科,阳新435200

出　　处：《广西医科大学学报》2017年第1期73-76,共4页Journal of Guangxi Medical University

摘　　要：目的:对比单纯胬肉切除、角膜缘干细胞移植与带蒂结膜瓣移植术治疗翼状胬肉的临床效果。方法:收集2008年1月至2014年10月湖北省阳新县人民医院眼科收治的翼状胬肉患者76例(120眼),根据手术方案不同将其分为A组(单纯胬肉切除术)、B组(角膜缘干细胞移植术)、C组(带蒂结膜瓣移植术),每组40眼。观察3组患者术后刺激症状、角膜云翳发生情况以及翼状胬肉复发率。结果:B组术后1周及术后1个月轻度刺激症状发生率明显高于A组和C组(P<0.05),且术后3个月、6个月、12个月角膜云翳发生率均明显低于A组和C组(P<0.05)。B组术后3个月、6个月、12个月翼状胬肉复发率均明显低于A组,差异均有统计学意义(均P<0.05)。结论:角膜缘干细胞移植治疗翼状胬肉的临床疗效优于单纯胬肉切除以及带蒂结膜瓣移植,且安全性较高,值得临床推广应用。Objective:To observe the clinical effect of pterygium excision,limbal stem cell transplantation(LSCT)and pedicle conjunctival flap transplantation in the treatment of pterygium.Methods:76patients with pterygium(120eyes)treated in our hospital from January 2008 to October 2014 were selected,and divided into 3groups(40eyes per group):group A in which the patients received pterygium excision,group B in which the patients received LSCT and group C in which the patients received pedicle conjunctival flap transplantation.The irritation symptoms,the incidence of corneal nebula and recurrence rate of pterygium were compared among groups.Results:The incidence of mild irritation symptoms in group B was higher than those in group A and group C at 1week and 1month after operation(P <0.05).The incidence of corneal nebula in group B was lower than those in group A and group C at 3,6and 12 months after operation(P <0.05).The recurrence rate of pterygium in group B was lower than that in group A at 3,6and 12 months after operation(P <0.05).Conclusion:LSCT was effective and safe,and was better than either pterygium excision or pedicle conjunctival flap transplantation for the treatment of pterygium,which could be worthy of clinical application.

关 键 词：单纯胬肉切除 角膜缘干细胞移植 带蒂结膜瓣移植 翼状胬肉 

分 类 号：R779.6[医药卫生—眼科]