基线尿酸水平与缺血性脑卒中患者预后的相关性  

Correlation of baseline uric acid level and prognosis in patients with ischemic stroke

作　　者：卢丹丹[1] 王佩[1] 李轩[1] 万莉[1] 魏书艳[1] 张唯[1] 侯岚[1] 沈月[1] 

机构地区：[1]保定市第一中心医院神经内三科,河北保定071000

出　　处：《中风与神经疾病杂志》2016年第12期1115-1117,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨急性缺血性脑卒中患者基线尿酸水平与临床预后的相关性。方法收集240例急性缺血性脑卒中患者,并记录基线尿酸水平,根据基线尿酸水平将研究对象分为4组,比较发病14 d及发病90 d时的神经功能情况。结果随基线尿酸水平的增高,发病14 d时神经功能缺损情况较发病1 d时好转(P<0.05),4组间比较差异有统计学意义(P<0.05)。发病90 d时,基线尿酸水平越高,患者的转归良好率越增高(P<0.05),当尿酸高于289.55 mol/L,患者转归良好率明显增高,差异有统计学意义(P<0.05)。随尿酸水平的增高,患者发病90 d时的不良事件的发生率无明显变化,4组间比较差异无统计学意义(P>0.05)。结论基线尿酸水平越高,患者神经功能恢复及临床转归越好。且当尿酸高于289.55 mol/L,患者转归良好率明显增高。Objective To investigate the correlation of baseline serum uric acid level and clinical prognosis in pa -tients with acute ischemic stroke .Methods 240 patients with acute ischemic stroke were collected and their baseline uric acid levels were recorded .According to the baseline uric acid level ,the subjects were divided into 4 groups.The neurological function of 14 d and 90 d of all patients were compared after the onset of the disease .Results With the increase of uric acid , the neurological deficits were significantly improved on 14 d （P〈0.05）,the difference was statistically significant （P〈0.05）.And with the increase of uric acid,the patient’s recovery rate was significantly higher on 90 d.When the uric acid was higher than 289.55 mmol/L,the patients’ recovery rate was significantly higher ,the difference was statistically significant （P〈0.05）.With the increase of uric acid,there was no significant change in the incidence of adverse events during the 90 d（P〉0.05）.Conclusion When the baseline uric acid level is higher ,the neurological function recovery and prognosis is better . And when the uric acid was higher than 289.55 mmol/L,the patients with good prognosis rate increased significantly .

关 键 词：缺血性脑卒中 尿酸 神经功能恢复 氧化应激 

分 类 号：R743.3[医药卫生—神经病学与精神病学]