针刺内关预处理干预心肌缺血再灌注大鼠实验效应的系统评价  

Systemic Review on Neiguan Acupuncture Pretreatment for Myocardial Ischemia Reperfusion of Rat Experiments Effects

作　　者：李珩[1] 肖宁[2] 邵明璐[1] 李洋[1] 谭奇纹[1] 

机构地区：[1]山东中医药大学,济南250014 [2]山东中医药大学附属医院,济南250000

出　　处：《中国中医基础医学杂志》2016年第12期1665-1669,共5页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家自然科学基金面上项目(81373722)-针刺预处理对心肌缺血再灌注损伤保护作用机制及其信号途径的研究

摘　　要：目的:通过系统评价验证针刺内关预处理干预心肌缺血再灌注大鼠的有效性及相关作用机制。方法:通过检索有关针刺内关预处理干预心肌缺血再灌注大鼠的随机对照实验研究文献进行质量评价、数据提取,并利用Revman5.2.6软件进行Meta分析。结果:有10篇文献纳入评价,与空白组比较,模型组结扎冠脉后心电图ST段电位值升高,以及实验后血清LDH值升高、血清NO水平降低。与模型组比较,内关组结扎冠脉后心电图ST段电位值明显升高幅度小(MD=0.08,95%CI[0.05,0.11],Z=5.51,P<0.00001),再灌后心电图ST段电位值显著减低(MD=0.09,95%CI[0.06,0.13],Z=5.09,P<0.00001),血清LDH值明显降低(MD=2.94,95%CI[0.93,4.95],Z=2.87,P=0.004),心梗面积明显减小(MD=7.84,95%CI[3.12,12.56],Z=3.25,P=0.001),血清NO水平显著升高(MD=-61.99,95%CI[-112.86,-11.13],Z=2.39,P=0.02)。结论:冠脉结扎再灌的方法能够很好地模拟心肌缺血再灌注的病理变化过程,针刺内关预处理能够显著降低缺血再灌注对大鼠的心肌损伤,其机制可能与增加心肌缺血再灌注大鼠血清中NO含量有关。Objective： To evaluate the efficacy of Neiguan acupuncture pretreatment for myocardial ischemia reperfusion of rat experiments effects. Methods： Search for domestic randomized controlled experimental studies. Further,carrying on quality evaluation,data extraction,and Meta analysis on Revman 5. 2. 6 software. Results： 10 studies were included in this review. After coronary artery ligated,the ST segment of ECG,serum LDH and NO of model group were significantly different from normal group. Compared to model group,the ST segment of ECG of Neiguan group increasing range was lowered after ischemia,while the ST segment of ECG of Neiguan group infarct size was lowered after reperfusion,serum LDH was also lowered,infract size was decreased,serum NO was increased. Conclusion： Ligating coronary artery and reperfusion is a good method for simulating myocardial ischemia reperfusion,Neiguan acupuncture pretreatment could decrease the injury of myocardial ischemia reperfusion effectively,and the result of this meta-analysis indicated that serum NO elevation might be one of the mechanism of the therapy.

关 键 词：内关 心肌缺血再灌注 预处理 系统评价 

分 类 号：R-332[医药卫生]