恶性肿瘤腹腔淋巴结转移三维适形放疗的临床疗效观察  

Clinical Observation of Three-dimensional Conformal Radiotherapy for Metastasis of Abdominal Lymph Node

作　　者：徐文静 刘德干 翟晨彤 解军 

机构地区：[1]兴化市人民医院肿瘤科,江苏泰州225700

出　　处：《肿瘤基础与临床》2016年第5期400-404,共5页journal of basic and clinical oncology

基　　金：泰州市科技发展计划项目(编号:泰科[2012]153号)

摘　　要：目的观察三维适形放疗(3DCRT)治疗恶性肿瘤腹腔淋巴结转移的疗效及毒副反应。方法入组56例恶性肿瘤腹腔淋巴结转移患者接受3DCRT,原发灶也接受了根治性手术、根治性放疗或化疗。近期疗效按WHO实体肿瘤疗效标准评价,毒副反应按RTOG标准评价。结果治疗后KPS评分中位数提高15.4分。治疗结束后3个月,原发灶总有效率为80.4%(45/56)。近期疗效与淋巴结转移灶体积有关,病灶体积越小,效果越好。1、2、3 a生存率分别为57.1%(32/56)、30.4%(17/56)和7.1%(4/56)。I、Ⅱ度胃肠道反应发生率为55.4%(31/56)。结论 3DCRT用于恶性肿瘤腹腔淋巴结转移有较好的疗效、毒副反应较轻。Objective To evaluate the efficacy of three-dimensional conformal radiotherapy（ 3DCRT） for metastasis of abdominal lymph node. Methods The 56 patients with metastasis of abdominal lymph node were treated with3 DCRT. These patients had received radical therapy for their primary tumors. The efficacy and toxicities were evaluated according to WHO and RTOG criterion system. Results The median KPS score was raised 15. 4 score. Three months after irradiation,the total response rate were d 80. 4%（ 45/56）. The short-term efficacy was related to the lymph node volume,the smaller the volume,the better the response. The 1-,2-and 3-year survival rates were 57.1%（ 32/56）,30. 4%（ 17/56） and 7. 1%（ 4/56）,respectively. The incidence of gastrointestinal toxicities in GradeⅠ and Ⅱ were 55. 4%（ 31/56）. Conclusion 3DCRT can be considered as an effective and feasible approach for metastasis of abdominal lymph node,the toxicities were observed.

关 键 词：恶性肿瘤 腹腔淋巴结转移 三维适形放疗 

分 类 号：R730.6[医药卫生—肿瘤] R730.55[医药卫生—临床医学]