机构地区:[1]商丘市第一人民医院神经内科,476100 [2]中国医学科学院北京协和医院神经内科,100730
出 处:《中华老年医学杂志》2017年第1期32-36,共5页Chinese Journal of Geriatrics
基 金:河南省医学科技攻关计划项目(2011030040)
摘 要:目的探讨首发缺血性脑卒中(IS)偏侧肢体功能障碍患者远期生活质量(QOL)的影响因素。方法前瞻性研究,连续人选商丘市第一人民医院神经内科2012年11月至2013年7月入院的首发Is偏侧肢体功能障碍患者126例,人组后收集患者一般资料并采用美国国立卫生研究院卒中量表(NIHSS)、改良的Rankin Scale(MRS)评分进行评估,在患者发病后2~3年采用NIHSS、MRS评分、Barthel指数(BI)、脑卒中专用生活质量量表(SS-QOL)、汉密尔顿抑郁量表(HAMD)再次随访。通过单因素分析分别筛选出与远期QOL具有相关性的因素后,使用多元逐步回归对QOL的影响因素进行分析。结果首发Is偏侧肢体功能障碍患者远期QOL总分平均为(181.5±46.4)分,各单项评分精力(10.4±4.3)分、家庭角色(10.8±4.2)分、语言(21.2±6.2)分、活动(22.5±7.6)分、情绪(18.5±6.3)分、个性(10.1±4.4)分、自理能力(19.2±5.9)分、社会角色(16.1±7.o)分、思维(11.7±3.3)分、上肢功能(19.1±6.6)分、视力(14.0±2.O)分、工作/劳动(8.7±4.1)分。多元逐步回归结果显示,远期QOL影响因素包括远期NIHSS评分(β=-0.376,P〈0.01)、远期HAMD评分(β=0.375,P〈0.01)、有无高血压病史(β=-0.178,P〈0.05)。其中HAMD评分影响QOL的9个领域,其次是远期NIHSS评分影响QOL的6个领域。结论缺血性脑卒中偏侧肢体功能障碍患者远期QOL下降的预测因素包括远期NIHSS评分较重、远期卒中后抑郁症状较重、发病初期合并高血压病。提示身体结构和功能损伤的恢复、高血压的控制及卒中后抑郁症状的有效预防和治疗等可能是提高缺血性脑卒中偏侧肢体功能障碍患者远期QOL的重要措施。Objectives To investigate the factors influencing long-term quality of life(QOL)of patients with first-episode ischemic stroke(IS)and partial side limb dysfunction. Methods 126 cases of the first ischemic stroke patients with partial side limb dysfunction admitted to hospital from November 2012 to July 2013 in Shanghai First People's Hospital were selected. General information of patients was collected and evaluated using NIH Stroke Scale(NIHSS)and Modified Rankin Scale(MRS). Following-up was conducted using NIHSS, MRS, stroke specific quality of life(SS-QOL) and Hamilton Depression Scale(HAMD) during 2-3 years after stroke. Factors related to long-term QOL were screened by single factor analysis, then factors influencing QOL by multiple stepwise regression analysis. Results The average QOL score of patients with first IS partial side limb dysfunction was( 181.5 ~ 46.4)points scale, in each single scoring, the scale was ( 10.4±4.3) point s in energy, ( 10. 8±4.2) points in family roles, ( 21.8±6.2 ) points in language, ( 22. 5±7.6)points in activity, (18. 5!6.3)points in mood, (10. l!4. 4)in personality, (19.2±5.9)points in self- care ability, ( 16.1± 7.0) points in social roles, (11.65 ±3.31 ) points in thinking, ( 19. 1±6. 6) points in upper limb function, ( 14.0±2. 0) points in visual acuity, ( 8. 7±4. 1 ) points in work. The multiple regression analysis showed that the influencing factors of life quality included long-term NIHSS evaluation(β=-0. 376, P〈0. 01), HAMD evaluation(β= -0. 375, P〈0.01 ), hypertension history(β=-0.178, P〈0. 05). HAMD evaluation affected 9 fields of QOL, and NIHSS as long-term evaluation affected 6 fields of QOL. Conclusions Predictive factors for declined QOL of first-episode ischemic stroke patients with partial side limb dysfunction include higher NIHSS score, severer depression after long-term stroke and combined hypertension in the early stage. These indicate that recoveri
分 类 号:R743.3[医药卫生—神经病学与精神病学]
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