术后认知障碍危险因素分析及应对  

Analysis and Its Countermeasures of Risk Factors of Postoperative Cognitive Dysfunction

作　　者：吴倍 滕金亮[2] 王新生[1] 杨跃平[1] 

机构地区：[1]河北北方学院,河北张家口075000 [2]河北北方学院附属第一医院,河北张家口075000

出　　处：《河北北方学院学报（自然科学版）》2016年第12期40-43,共4页Journal of Hebei North University:Natural Science Edition

摘　　要：术后认知障碍(postoperative cognitive dysfunction,POCD)是临床术后常见中枢神经系统并发症,表现为记忆力受损、注意力不集中及学习能力、语言和思维能力下降等,患者日常生活质量下降,增加围术期并发症甚至死亡率,越来越受到社会及学术界重视。现有资料表明POCD发生与年龄有关,最近研究发现,术前基础疾病和用药、术中麻醉药物和手术方式的选择、术后疼痛和炎症等都能诱发POCD。深入研究POCD发生的危险因素及应对方案对预防其发生发展有重要意义。Postoperative cognitive dysfunction （POCD） is a central nervous system complication afterthe operation. It represents a syndrome of disruption of memory, concentration, impaired ability oflearning, language and thinking. Additionally, it would have a negative effect on patients quality of lifeand contribute greatly to perioperative morbidity and mortality, which have drawn significant attentionfrom the public and academic community. Available clinical and preclinical evidences indicate a link be-tween age and cognitive deficits, but recent studies have shown that preoperative basic diseases and medi-cation, anesthesia and surgical methods, postoperative pain and inflammation can induce the occurrence ofPOCD. So studying the risk factors of POCD and the solutions is very significant to prevent it.

关 键 词：术后认知障碍 七氟烷 异氟烷 中枢神经系统炎症 

分 类 号：R749.1[医药卫生—神经病学与精神病学]