频发短暂性脑缺血发作患者的血管病变和临床特点分析  

Vascular lesions and clinical analysis of patients with frequent transient ischemic attack

作　　者：张庆涛 耿德勤 

机构地区：[1]徐州医科大学附属第三医院神经内科,江苏徐州221003 [2]徐州医科大学附属医院神经内科,江苏徐州221002

出　　处：《徐州医学院学报》2016年第12期802-804,共3页Acta Academiae Medicinae Xuzhou

摘　　要：目的探讨频发短暂性脑缺血发作（TIA）患者的临床特征和颅内外血管狭窄的特点。方法将98例TIA住院患者分为频发组和非频发组，频发组39例，非频发组59例，对其临床特征和颅内外血管狭窄的特点进行回顾性分析。结果2组间在供血系统、是否老年、性别及是否合并高血压、糖尿病、高脂血症等方面的差异无统计学意义（P〉0．05）。频发组症状持续时间短暂（≤10rain）发生率、进展为卒中发生率均高于非频发组，差异有统计学意义（P〈0．05）。频发组血管狭窄率、狭窄程度及狭窄血管数量均高于非频发组，频发组较少伴易损斑块，差异均有统计学意义（P〈0．05）。多因素回归分析显示，血管狭窄程度高及较少伴有易损斑块是频发TIA的独立危险因素。结论频发TIA患者血管狭窄率高，狭窄数量多，狭窄程度高，较少伴有易损斑块，其临床症状持续时间较短，但更容易进展为卒中。血管狭窄程度高及较少伴有易损斑块是频发TIA的独立危险因素。Objective To investigate the clinical characteristics of patients with frequent transient ischemic attack （TIA） and the features of intra - and extra - cranial vascular stenosis. Methods A total of 98 TIA patients who were admitted into our hospital from January 2010 to December 2015 were included into the current study. They were divided into a fre- quent group and a non -frequent group. Retrospective analysis was performed to investigate the clinical characteristics of TIA patients and the features of intra - and extra - cranial vascular stenosis. Results There was no statistical signifi- cance in blood supply system, age, gender, hypertension, diabetes or hyperlipidemia between the two groups （P 〉 0.05）. The incidences of transient duration of symptoms and stroke were higher in the frequent group than those in the non - frequent group （ P 〈 0.05 ）. The frequent group produced increases in the rate of vascular stenosis, stenosis degree and the number of vascular stenosis with less plaques that were easily fragile, compared with the non - frequent group （P 〈0.05）. According to logistic regression analysis, a higher degree of vascular stenosis （P 〈0. 05, OR = 17.55） and a smaller number of fragile plaques （P 〈 0. 05, OR = 0.01 ） were independent risk factors for frequent transient ischemic attack. Conclusions Frequent TIA patients show increases in the rate of vascular stenosis, stenosis degree and the num- ber of vascular stenosis, with less plagues that are easily fragile. Although their clinical symptom duration is shorter, they are more likely to progress into stroke. A higher degree of vascular stenosis and with a small number of fragile plaque are independent risk factors for frequent TIA.

关 键 词：短暂性脑缺血发作 频发 血管狭窄 

分 类 号：R743.31[医药卫生—神经病学与精神病学]