紫杉醇过敏预处理中胃酸抑制剂的疗效评价研究  

Evaluation of the efficacy of gastric acidity inhibitors in the management of paclitaxel hypersensitivity reaction

作　　者：李莲 胡丽丽 朱正秋 高超 吕冬梅 

机构地区：[1]徐州医科大学第二附属医院药剂科,江苏徐州221006 [2]徐州医学大学附属医院药学部,江苏徐州221006 [3]徐州医科大学附属医院肿瘤内科

出　　处：《徐州医学院学报》2016年第12期844-847,共4页Acta Academiae Medicinae Xuzhou

摘　　要：目的比较2种不同的胃酸抑制剂奥美拉唑与雷尼替丁在紫杉醇过敏预处理方案中疗效的差异。方法收集2014年5月—2016年4月使用紫杉醇化疗的患者100例，随机分为实验组50例、对照组50例，比较2组使用紫杉醇后过敏反应的发生率、反应程度，并进行药物经济学分析。结果对照组的过敏反应率为12％，实验组的过敏反应发生率为14％，2组差异无统计学意义。上述过敏反应多为Ⅰ～Ⅱ度，未见严重过敏反应。实验组的治疗成本高于对照组。结论紫杉醇化疗前应用奥美拉唑和雷尼替丁处理，均可产生较好的预防作用。奥美拉唑的治疗成本较高，临床上使用奥美拉唑取代说明书方案的应用不合理，应予以纠正。Objective To compare the efficacy of two different gastric acidity inhibitors, omeprazole and ranitidine, in the management of paclitaxel hypersensitivity reactions. Methods A total of 100 malignant tumor patients who received paclitaxel chemotherapy form May 2014 to April 2016 were included into the current study. They were randomly divided into a control group and an experimental group （n = 50）. Both groups were compared for the incidence and de- gree of hypersensitivity reaction of paclitaxel and pharmaeoeconomic analysis. Results The hypersensitivity incidence was 12% for the control group and 14% for the experimental group, which were not statistically different. The most of hy- persensitivity reactions were Ⅰ toⅡ degrees, without severe allergic reaction. The experimental group cost more than the control group. Conclusion Both omeprazole and ranitidine can produce good preventive effects before paclitaxel chemo- therapy. With respect to the highercost of omeprazole, it may not be rational to use this agent in stead of the instructed regimen which should be corrected.

关 键 词：紫杉醇 过敏预处理 胃酸抑制剂 

分 类 号：R730.5[医药卫生—肿瘤]