RNF180在肝细胞癌中的表达及临床意义  

Expression of ring finger protein 180 in hepatocellular carcinoma and its clinical significance

作　　者：赵慧金[1] 张宁[1] 张兰[1] 李胜棉[1] 

机构地区：[1]河北医科大学第四医院消化内科,河北石家庄050011

出　　处：《肿瘤》2017年第1期83-88,共6页Tumor

摘　　要：目的 :探讨抑癌基因环指蛋白180(ring finger protein 180,RNF180)在肝细胞癌及癌旁肝硬化组织中的表达情况及临床意义。方法 :采用免疫组织化学法检测76例肝细胞癌及其对应癌旁肝硬化组织中RNF180的表达情况,并分析肝细胞癌中RNF180的表达与临床病理特征及生存期预后的关系。结果 :RNF180在肝癌组织中的阳性表达率为39.47%(30/76),明显低于癌旁肝硬化组织中的阳性表达率86.84(%66/76),差异有统计学意义(P=0.006);且肝细胞癌组织中RNF180的表达强度明显低于癌旁肝硬化组织(Z=-2.480,P=0.013)。RNF180的阳性表达率在AFP≤200μg/L的肝细胞癌中明显高于AFP>200μg/L的肝细胞癌组织(P=0.031)。RNF180表达阴性组患者的平均生存期为(16.42±6.39)个月,而表达阳性组为(20.40±5.86)个月,差异有统计学意义(P=0.002)。COX多因素分析结果提示,有无门静脉癌栓、肿瘤个数和RNF180表达为影响肝癌患者预后的独立因素。结论 :抑癌基因RNF180在一定程度上参与了肝细胞癌的发生,促进了肝细胞癌的发展进程,RNF180可能成为肝细胞癌诊断、病情判断及预后预测的新的分子标志。Objective： To compare the expression level of tumor suppressor ring finger protein 180 （RNF180） in hepatocellular carcinoma （HCC） tissues and adjacent cirrhosis tissues, and to investigate the clinical significance of RNF180 expression. Methods： The expression of RNF180 in HCC tissues and their corresponding adjacent cirrhosis tissues from 76 patients was detected by immunohistochemistry. The relationships of RNF180 expression with clinicopathological parameters and survival time of patients with HCC were analyzed. Results： The positive rate of RNF180 expression in HCC tissues was significantly lower than that in adjacent cirrhosis tissues （39.47% vs 86.84%, P = 0.006）, and the intensity of RNF180 expression in HCC tissues was significantly lower than that in cirrhosis tissues （Z = -2.480, P = 0.013）. The positive rate of RNF180 expression in alpha-fetoprotein （AFP）≤200 μg/L group was significantly higher than that in AFP 〉 200μg/L group （P = 0.031）. The postoperative overall survival time of patients with negative expression of RNF180 was significantly shorter than that of patients with positive expression of RNF180 [（16.42±6.39） vs （20.40±5.86） months, P = 0.002]. Multivariate analysis showed that portal vein tumor thrombosis, the number of tumor lesions and RNF180 expression were independent prognostic factors for HCC patients （all P 〈 0.05）. Conclusion： Tumor suppressor RNF180 is partly involved in the occurrence of HCC, and promotes the development of HCC. It suggests that RNF180 may act as a new tumor molecular marker for the diagnosis, severity evaluation and prognosis prediction of HCC.

关 键 词：癌 肝细胞 免疫组织化学 环指蛋白180 预后 

分 类 号：R735.7[医药卫生—肿瘤]