P200复合波在记忆障碍患者中的诊断价值  

Value of P200 compositive wave in diagnosis of memory impairment

作　　者：刘美英[1] 黄苗苗[1] 房哲[1] 李波翰[1] 刘斌[1] 朱梅佳[2] 

机构地区：[1]山东大学第二医院健康管理中心,济南250033 [2]山东省千佛山医院神经内科

出　　处：《中华老年心脑血管病杂志》2017年第1期70-73,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的探讨脑白质疏松(leukoaraiosis,LA)患者图片刺激事件相关电位(event related potential,ERP)的特征,寻找早期发现和评价LA患者记忆障碍的新方法,提高认知损害的诊断水平。方法连续选择2010年6月~2011年3月在我院经MRI检查确诊为LA的患者30例作为LA组,同时选取健康体检者30例作为对照组,对所有受试者应用学习再认试验范式进行图片刺激,同时记录脑电图,离线处理后对2组受试者所诱发的ERP进行分析比较。结果单纯记忆任务范式图片刺激相关的ERP主要成分为P200,学习与再认过程均未出现明显的N100及P300波。图片再认过程中,对照组旧图图片刺激诱发的P200波幅明显高于新图[(10.08±0.98)μVvs(8.45±1.16)μV,P=0.000],LA组旧图图片刺激诱发的P200波幅与新图无统计学差异[(10.52±1.52)μVvs(11.12±2.99)μV,P=0.331]结论 LA患者存在记忆受损,P200可作为早期评价LA患者记忆受损的辅助工具。Objective To improve the diagnosis of memory impairment by studying the characteristics of events-related potentials（ERP）in leukoaraiosis（LA）patients.Methods Thirty MRI-confirmed LA patients served as a LA group and 30 healthy elderly subjects served as a control group in this study.They underwent MOCA test,image study recognition test,and EEG.The off-line ERP were comparatively analyzed.Results The main component of ERP was P200 wave.Image study recognition test showed no significant N100 and P300waves,and dispayed that the amplitude of P200 wave was significantly smaller in new images than in old ones of control group and LA group（10.08±0.98μVvs 8.45±1.16μV,P=0.000,10.52±1.52μVvs 11.12±2.99μV,P=0.331）.Conclusion LA patients suffer from memory impairment.P200 wave can be used as an accessory tool in early diagnosis of memory impairment in LA patients.

关 键 词：脑白质疏松症 诱发电位 记忆障碍 磁共振成像 

分 类 号：R749.13[医药卫生—神经病学与精神病学]