不同病种IMRT计划验证通过率差异分析  

The differences among the pass rate of intensity modulated radiation therapy planning in different tumors

作　　者：王勇[1] 李俊萍[1] 张玲玲[1] 王开铭[1] 蔡文杰[1] 

机构地区：[1]福建医科大学附属泉州第一医院放疗科,362000

出　　处：《中华放射肿瘤学杂志》2017年第1期50-52,共3页Chinese Journal of Radiation Oncology

摘　　要：目的 研究不同病种IMRT计划通过率之间差异性及在确定通过率阀值的应用。方法 连续选取已验证过的食管癌、鼻咽癌、乳腺癌、宫颈癌、肺癌IMRT计划各35例,使用一维方差分析方法检验通过率差异性。分析采用单一通过率阀值检验各种IMRT计划,并依据正态分布规律计算不同肿瘤IMRT计划验证通过率阈值。结果 5组数据的组间平均值差异有统计学意义（F=35.83,P〈0.01）,其中鼻咽癌组与其他四组之间统计结果均为P=0.000;乳腺癌组与食管癌组、肺癌组之间统计结果分别为P=0.001、P=0.033。使用单一阀值检验所有计划是不合适的,应使用各自阀值,各组阀值计算结果分别为93.37%、89.34%、97.68%、95.99%、95.42%。结论 不同病种计划应使用不同阀值,正态分布规律可以计算各自阀值。Objective To investigate the difference in the pass rate of intensity-modulated radiation therapy （IMRT） planning in patients with different tumors and its value in determining pass rate thresholds. Methods A total of 35 verified IMRT plans for each of esophageal cancer, nasopharyngeal carcinoma, breast cancer, cervical cancer, and lung cancer were selected consecutively, and a one-way analysis of variance was used to investigate the difference in pass rate. A single pass rate threshold was used to test all IMRT plans, and the pass rate thresholds of IMRT plans for different tumors were calculated based on normal distribution law. Results There was a significant difference in the means between the 5 groups of data （F=35.83, P〈0.01）, and there was also a significant difference between any two groups （P=0.000）.There were statistically significant differences between nasopharyngeal carcinoma group and other four groups （P=0.000）. The difference was not only significant between the breast cancer group and the esophageal cancer group （P=0.001）, but also between the breast cancer group and the lung cancer group （P=0.033）. The calculated results of each threshold were 93.37%, 89.34%, 97.68%, 95.99%, and 95.42%, respectively. Conclusions Different thresholds should be used for IMRT plans for different tumors, and the normal distribution law can be used to calculate the threshold.

关 键 词：调强放疗计划 剂量验证 质量控制 

分 类 号：R730.55[医药卫生—肿瘤]