新辅助治疗对早期巨块型宫颈癌的临床疗效  

Clinical efficacy of neoadjuvant treatment on early stage bulky cervical carcinoma

作　　者：关明飞[1] 朱安娜[1] 李燕[1] 周莉[1] 王旖旎[1] 李从铸[1] 黄萍[1] 

机构地区：[1]汕头大学医学院附属肿瘤医院妇科,广东省汕头515031

出　　处：《中国医师杂志》2016年第12期1797-1800,共4页Journal of Chinese Physician

基　　金：广东省医学科学技术研究基金项目资助（20151222239423）

摘　　要：目的探讨新辅助治疗对早期巨块型宫颈癌的近期及远期疗效。方法回顾性分析2010年11月至2015年2月在汕头大学医学院附属肿瘤医院收治的155例局部晚期宫颈癌（局部肿瘤〉4cm的Ib：或Ⅱa2期）患者，其中新辅助治疗组108例，直接手术组47例，收集其临床病理资料，并随访患者生存情况。结果新辅助治疗组的总有效率为75．0％，新辅助治疗组的肿瘤分化程度较高（P=0．000），深肌层浸润的发生率有下降的趋势（49．1％VS63．8％，P=0．090）；两组患者肿瘤病理类型、宫旁浸润、淋巴结转移、淋巴脉管间隙浸润的情况差异无统计学意义（P〉0．05）；新辅助治疗组术后辅助治疗率为92．6％，直接手术组为87．2％，两组差异无统计学意义（P〉0．05）。新辅助治疗组及直接手术组的总生存率分别为96．4％和88．9％，差异无统计学意义（P=0．069）。结论新辅助治疗对早期巨块型宫颈癌有较好的近期疗效，可以改善肿瘤的分化程度，有延长早期巨块型宫颈癌患者生存期的潜能。Objective To evaluate clinical efficacy and survival outcomes of neoadjuvant treatment on early stage bulky cervical carcinoma. Methods A total of 155 cases with bulky stage I b2 or 11 a2 cervical carcinoma in Affiliated Tumor Hospital of Shantou University Medical College from Nov. 2010 to Feb. 2015 was reviewed and divided into two groups according to pre-operative treatment 108 cases in the neoad- juvant treatment group and 47 cases in the control group who underwent radical surgery directly. The clinical, pathologic, and follow-up data were analyzed retrospectively. Results The total response rate of neo- adjuvant treatment was 75.0%. Histological grade in neoadjuvant treatment group was better than the other group and the rate of deep myometrial infiltration was tend to low in neoadjuvant treatment group. There was no difference in pathological type, parametrial involvement, lymph node metastasis, and lymph vascular space invasion between two groups. The rate of postoperative treatment was similar （ 92. 6% vs 87. 2%, P 〉 0.05 ）. The overall survival rate of neoadjuvant treatment group was 96. 4% and the other group was 88. 9% （P = 0. 069）. Conclusions Neoadjuvant treatment was effective for early stage bulky cervical carcinoma. It might reduce tumor histological grade and maybe improve the overall survival of patients.

关 键 词：化学疗法 辅助 放射疗法 辅助 宫颈肿瘤/治疗 

分 类 号：R737.33[医药卫生—肿瘤]