直肠癌患者D型人格与生存质量及预后的关系  

Type D personality is associated with poor quality of life and prognosis among rectal cancer survivors

作　　者：张家魁[1] 李永双[1] 金俊哲[1] 刘继超[1] 张春东[1] 戴冬秋[1] 

机构地区：[1]中国医科大学附属第四医院胃肠外科,辽宁沈阳110032

出　　处：《现代肿瘤医学》2017年第3期415-422,共8页Journal of Modern Oncology

摘　　要：目的:探索直肠癌患者D型人格(type D personality)与预后及术后生存质量(quality of life,QOL)之间的关系。方法:D型人格的分析使用14项D型人格量表(DS14)。生存质量(QOL)结果的评估应用European Organization for Research and Treatment of Cancer QLQ-C30和QLQ-CR38问卷对基线和诊断后6个月的直肠癌患者进行评估。结果:实验入组511名受试者,反应率93%,其中有112名受试者具有D型人格(22%)。在基线及诊断后6个月两个时间点的横向比较中,D型人格组在大部分功能量表及整体健康状态评分方面显著低于非D型人格组,并且拥有更严重的症状评分。在诊断后6个月时间点,D型人格组受试者有更高比例的QOL恶化。结论:在直肠癌患者中,D型人格与不佳的生存质量及预后显著相关。D型人格是临床实践当中预测直肠癌患者生存质量恶化的重要易感因素。Objective：To explore the relationship between quality of life（QOL）and type D personality of rectal cancer patients. Methods：Type D personality was measured with the 14 - item Type D Personality Scale（DS14）. The QOL outcomes were assessed longitudinally using the European Organization for Research and Treatment of Cancer QLQ - C30 and QLQ - CR38 questionnaires at the baseline and 6 months after diagnosis. Results：A total of 511 subi-ects,responce rate（93% ）,112（22% ）of which had a type D personality. At both of the time points,type D petson-ality reported statistically significant lower scores on most of the functional scales,global health status/ QOL scales, and worse symptom scores compared to patients without a type D personality. At the 6 - month time point,a higher percentage of patients in the type D group demonstrated QOL deterioration. Conclusion：Type D personality was asso-ciated with poor QOL and prognosis among survivors of rectal cancer,even after adjustment for confounding back-ground variables. Type D personality might be a general vulnerability factor to screen for subgroups at risk for QOL de-terioration in clinical practice.

关 键 词：直肠癌 D 型人格 生存质量 预后 

分 类 号：R735.37[医药卫生—肿瘤]