长非编码RNA BANCR在肿瘤研究中的进展  

Research advances of long non-coding RNA BANCR in the development of human carcinomas

作　　者：汤菁[1] 王朝霞[2] 

机构地区：[1]南京医科大学第一临床医学院临床医学系,江苏南京210029 [2]南京医科大学第二附属医院肿瘤科,江苏南京210011

出　　处：《现代肿瘤医学》2017年第3期478-482,共5页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:81472198;81272601);江苏省科技厅临床医学科技专项(编号:BL2014096);江苏省医学重点人才基金(编号:RC2011080)

摘　　要：BANCR在黑色素瘤、肝癌、胃癌、视网膜母细胞瘤、骨肉瘤和食管鳞癌中高表达,扮演着癌基因的角色;在肺癌和膀胱癌中低表达,起着抑癌基因的作用。BANCR在肿瘤细胞的增殖、侵袭、转移和凋亡过程中发挥重要作用,因此有望成为新型肿瘤标志物和肿瘤临床治疗的新靶点,可用于肿瘤早期诊断、治疗及监测预后。本文结合国内外最新报道,对lncRNA BANCR在各种肿瘤研究中的进展做一综述。LncRNA BANCR expression has been confirmed in different tumors. BANCR,acting as oncogene,it was abnormally overexpressed in melanoma,hepatocellular cancer,gastric cancer,osteosarcoma,retinoblastoma,esophageal squamous cell carcinoma. Downregulation of BANCR expression in lung cancer and bladder cancer indicates that BANCR also plays the role of tumor suppressor gene. BANCR contributes to tumor proliferation,invasion and migra-tion,so it＆#39; emerging as novel tumor markers and potential targets for the treatment,diagnosis and prognosis of early -stage cancer. In this review,we summarize the latest progresses,both domestic and overseas,on the research of BAN-CR in various human carcinomas.

关 键 词：长非编码RNA BANCR 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]