正天丸联合尼莫地平治疗血瘀阻络型偏头痛疗效及对血液流变学、血管活性物质影响研究  

Effect on hemorheology and vasoactive substances of Zhengtianwan combined with nimodipine in the treatment of blood stasis blocking collaterals type of migraine

作　　者：梁天山[1] 吴艳华[1] 李慧[1] 徐念[1] 

机构地区：[1]广州市红十字会医院,广州510220

出　　处：《陕西中医》2017年第1期3-5,共3页Shaanxi Journal of Traditional Chinese Medicine

基　　金：广东省科技计划项目(2012B061700018)

摘　　要：目的:观察正天丸联合尼莫地平治疗血瘀阻络型偏头痛的疗效及对血液流变学、血管活性物质的影响。方法:将纳入研究的167例血瘀阻络型偏头痛发作期患者抽签随机分为观察组(87例)和对照组(80例)。对照组给予生活干预及尼莫地平治疗,观察组在对照组的基础上采用正天丸治疗。治疗3个月,观察两组疗效及血液流变指标[全血黏度(高切、低切)、血浆黏度]、血浆血管活性物质(TXB2、ET-1、NO、DA、5-HT)变化。结果:观察组总有效率93.10%,对照组有效率77.50%,两组总有效率比较差异有统计学意义(P<0.05);治疗后,两组全血黏度(高切、低切)、血浆黏度、HCT均明显下降(P<0.05);两组TXB2、ET-1明显下降而NO、DA、5-HT明显上升(P<0.05),且观察组上述各指标变化幅度更大,两组各指标同期比较差异有统计学意义(P<0.05)。结论:正天丸可显著提高血瘀阻络型偏头痛的临床疗效,作用机制应与改善血液流变及血管活性物质水平有关。Objective：To observe the efficacy on hemorheology and vasoactive substances of Zhengtianwan combined with nimodipine in the treatmenting of migraine of blood stasis blocking collaterals.Methods：167cases of patients included in the study were divided into the observation group（87cases）and the control group（80cases）.The control group was given life intervention and nimodipine,and the observation group was given Zhengtianwan based on the control group.For 3 months,the efficacy and the changes of hemorheology and vasoactive substances were observed between the two groups.Results：In the observation group,the total efficiency was 93.10%,the control group total efficiency was 77.50%,with significant difference（P〈0.05）;After treatment,the two group of whole blood viscosity（high and low shear）,plasma viscosity were decreased（P〈0.05）,TXB2、ET-1were decreased and NO、DA、5-HT were increased（P〈0.05）,all indexs of observation group were improved obvious than that of the control group,with significant difference（P〈0.05）.Conclusion：Zhengtianwan combined with nimodipine can effectively improve the curative effect of blood stasis blocking collaterals type of migraine,and its mechanism should be related to improving hemorheology and concentration of vasoactive substances.

关 键 词：偏头痛/中西医结合疗法 @正天丸 尼莫地平 

分 类 号：R747.2[医药卫生—神经病学与精神病学]