C反应蛋白和补体C3在肺癌转移鉴别诊断中的应用研究  

Application of C-reactive Protein and Complement C3 in the Differential Diagnosis of Lung Cancer Metastasis

作　　者：刘妍妍[1] 王然[1] 杨泳滨 崔丹[1] 李春红[2] 

机构地区：[1]哈尔滨医科大学生理教研室,黑龙江哈尔滨150081 [2]哈尔滨医科大学附属肿瘤医院肿瘤内科,黑龙江哈尔滨150081

出　　处：《世界复合医学》2016年第4期7-9,共3页World Journal of Complex Medicine

基　　金：黑龙江省卫生计生委科研课题(2014-413)

摘　　要：目的研究C反应蛋白及补体C3在肺癌转移鉴别诊断中的应用价值。方法选取该院于2015年6月—2016年6月收治的64例肺癌患者为研究对象,并将其按照肺癌的转移情况分为实验组与对照组,每组32例。对上述患者的C反应蛋白（CRP）、补体C3、血浆纤维蛋白原（Fib）及全血白细胞计数（WBC）进行检测,并对其各项指标的阳性率进行计算。结果经检测,实验组患者的CRP、补体C3水平分别为（19.67±4.59）mg/L及（1.09±0.43）g/L,均明显高于对照组患者同期的（12.39±3.77）mg/L及（0.67±0.24）g/L,比较差异均具有统计学意义（P〈0.05）;实验组患者的Fib浓度为（2.39±0.86）g/L,明显低于对照组患者同期的（3.21±0.67）g/L,比较差异具有统计学意义（P〈0.05）;实验组患者的WBC计数为（6.33±0.97）×10~9/L,与对照组患者同期的（6.41±1.03）×10~9/L的比较差异无统计学意义（P〉0.05）。实验组患者的CRP、补体C3、CRP＋补体C3组合阳性率分别为78.13%、65.63%、100.00%,均明显高于对照组患者的59.38%、53.13%、71.88%,比较差异具有统计学意义（P〈0.05）;实验组患者的WBC及Fib阳性率分别为46.88%及40.63%,与对照组患者的43.75%及37.50%的比较差异无统计学意义（P〉0.05）。结论对肺癌患者的CRP及补体C3水平同时进行测定可以作为其肿瘤是否转移的一个重要依据,具有较高的临床诊断价值。Objective To study the value of C-reactive protein and complement C3 in the differential diagnosis of lung cancer metastasis.Methods Sixty-four patients with lung cancer admitted in our hospital from June 2015 to June 2016 were selected and divided into experimental group and control group according to the metastasis of lung cancer.（CRP）,complement C3,plasma fibrinogen（Fib） and whole blood white blood cell count（WBC） were measured and the positive rate of each index was calculated.Results The levels of CRP and complement C3 were（19.67±4.59） mg/L and（1.09±0.43） g/L,respectively,which were significantly higher in the experimental group than those in the control group（12.39±3.77） mg/L and（0.67±0.24） g/L,respectively,and the difference was statistically significant（P 〈0.05）.The Fib concentration in the experimental group（2.39 ±0.86） g/L、was lower than that in the control group（3.21 ±0.67） g/L and the difference was statistically significant.The WBC count in the experimental group was（6.33±0.97）×10~9/L,compared with the control group（6.41±1.03）×10~9/L was not statistically significant（P〉 0.05）.The positive rate of CRP,complement C3,CRP ＋complement C3 were 78.13%,65.63% and 100.00% respectively in the experimental group,which were significantly higher than those in the control group（59.38%,53.13%,71.88%）,and the difference was statistically significant（P 〈0.05）.The positive rate of WBC and Fib in experimental group was 46.88% and 40.63% respectively,which was not significantly different from that in control group（43.75% vs 37.50%）.Conclusion The determination of CRP and complement C3 levels in patients with lung cancer can be used as an important basis for the metastasis of lung cancer and has a high clinical diagnostic value.

关 键 词：C反应蛋白 补体C3 肺癌转移 

分 类 号：R734.2[医药卫生—肿瘤]