青脆枝化学成分及其活性研究进展  

Research Progress on Chemical Constituents and Biological Activity of Nothapodytes nimmoniana

作　　者：沈瑞池[1] 吴美芳[1] 何恩铭[1] 陈德林[1] 王杰[1] 何建章[1] 周爽[1] 

机构地区：[1]福建省亚热带植物研究所,福建省亚热带植物生理生化重点实验室,福建厦门361006

出　　处：《亚热带植物科学》2016年第4期379-385,共7页Subtropical Plant Science

基　　金：厦门市科技计划项目(3502Z20141041、3502Z20151245、3502Z20150057、3502Z20162010);厦门市重大科技创新平台项目(3502Z20131004);福建省亚热带植物研究所基金项目(2015S004、2015S005)

摘　　要：喜树碱是已发现的唯一专门通过抑制拓扑异构酶Ⅰ发挥细胞毒性的天然植物成分,具有广谱抗肿瘤活性。青脆枝Nothapodytes nimmoniana含有多种喜树碱类化合物及其他活性成分,其中喜树碱、9-甲氧基喜树碱和羟基喜树碱含量最为丰富,是重要的药用植物。文中综述青脆枝主要化学成分、生物活性及其提取方法,并对青脆枝的应用前景作展望。Camptothecin（CPT） is a cytotoxic quinoline alkaloid which is only one specially inhibiting the DNA enzyme topoisomerase I（topo I）, showes remarkable anticancer activity. There are many CPTs and other active ingredients in Nothapodytes nimmoniana, the contents of CPT, 9-methoxycamptothecin and hydroxycamptothecin in Nothapodytes nimmoniana are most abundant. N. nimmoniana have become an important medicinal plant. In this paper, the chemical constituents, their biological activity and extraction methods of N. nimmoniana were summarized. In addition, the development and utilization prospect of N. nimmoniana were introduced.

关 键 词：青脆枝 喜树碱 化学成分 生物活性 提取 

分 类 号：Q946.8[生物学—植物学]