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作 者:王耀辉[1] 高丽丽[1] 刘春样[1] 王洁[1] 王剑蓉[1]
机构地区:[1]南京中医药大学附属医院病理科,南京210029
出 处:《中华实用诊断与治疗杂志》2017年第1期51-53,共3页Journal of Chinese Practical Diagnosis and Therapy
基 金:江苏高校优势学科建设工程资助项目(012062003010);江苏省中医院院级课题(Y14078)
摘 要:目的探讨Toll样受体2(Toll-like receptor 2,TLR2)和转化生长因子-β(transforming growth factor-β,TGF-β)在溃疡性结肠炎(ulcerative colitis,UC)发病机制、病情进展中的作用。方法 UC患者20例,分别于急性期、缓解期行肠镜检查,急性期活检组织标本为急性期组,缓解期活检组织标本为缓解期组;同期UC伴上皮内瘤变患者30例活检组织标本为上皮内瘤变组;采用免疫组织化学法检测3组TLR2、TGF-β蛋白表达水平。结果肠黏膜TLR2、TGF-β蛋白水平在急性期组(2.10±0.55、11.20±1.64),上皮内瘤变组(2.26±0.83、10.70±1.92)均高于缓解期组(0.55±0.51、1.65±0.59)(P<0.05);急性期组和上皮内瘤变组TLR2、TGF-β蛋白表达水平比较差异均无统计学意义(P>0.05);TLR2、TGF-β蛋白在急性期组、缓解期组、上皮内瘤变组肠黏膜组织中表达均无相关性(r=0.108,P=0.652;r=0.235,P=0.319;r=0.114,P=0.550)。结论 TLR2、TGF-β蛋白在UC急性期呈高表达,肠黏膜TLR2、TGF-β蛋白水平可作为判断UC病情进展的辅助参考指标。Objective To explore the roles of Toll-like receptor 2 (TLR2) and transforming growth factor-β (TGF-β) protein in the pathogenesis and progression of ulcerative colitis (UC). Methods The expression levels of TLR2 and TGF-β were detected by immunohistoehemistry in 20 UC patients in acute (acute stage group) and their corresponding remission stage (remission stage group) and 30 UC patients complicated with intraepithelial neoplasia (intraepithelial neoplasia group). Results The expressions of TLR2 and TGF-β protein were significantly higher in acute stage group (2.10±0.55, 11.20±1.64) and intraepithelial neoplasia group (2.26±0.83, 10. 70±1. 92) than those in remission stage group (0.55±0.51, 1.65±0.59) (P〈0.05), and there were no significant differences between acute stage group and intraepithelial neoplasia group (P〉0.05). There was no significant difference in the levels of TLR2 and TGF-β in acute stage group, remission stage group and intraepithelial neoplasia group (r=0. 108, P=0. 652; r= -0. 235, P= 0. 319; r= 0. 114, P=0. 550). Conclusion TLR2 and TGF-β are highly expressed in acute stage in UC patients, and can be used as auxiliary reference indexes for evaluating the development of UC.
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