VEGFR2+1416 T/A基因多态性与抑郁症关系  

Association between gene polymorphism of vascular endothelial growth factor receptor 2 and susceptibility of major depressive disorders

作　　者：乔正学[1] 马靖松[1] 陈明琪[2] 杨佳润 邱晓惠[1] 杨秀贤[1] 王琳[1] 杨艳杰[1] 

机构地区：[1]哈尔滨医科大学公共卫生学院医学心理学教研室,黑龙江哈尔滨150086 [2]齐齐哈尔医学院公共卫生学院

出　　处：《中国公共卫生》2017年第1期122-124,共3页Chinese Journal of Public Health

基　　金：国家自然科学基金(81302484;81473054)

摘　　要：目的探讨血管内皮细胞生长因子受体2(VEGFR2)+1416 T/A基因多态性与抑郁症易感性的关系。方法提取中国北方地区274名汉族单相抑郁症患者(病例组)和273例汉族健康对照者(对照组)基因组DNA,采用单碱基延伸SNP分型技术(SNa Pshot)检测病例组和对照组VEGF R2+1416 T/A位点基因型,应用χ2检验比较病例组和对照组的基因型和等位基因频率分布的差异。结果病例组和对照组VEGFR2+1416 T/A基因型A/A、A/T、T/T频率分布为26.3%、44.9%、28.8%和16.8%、54.6%、28.6%,差异有统计学意义(χ2=8.219,P=0.016),病例组和对照组VEGFR2+1416 T/A等位基因A、T频率分布为48.7%、51.3%和44.1%、55.9%,差异无统计学意义(χ2=2.310,P=0.129)。结论 VEGFR2+1416 T/A基因多态性与抑郁症有明显关联。Objective To investigate the relationship between vascular endothelial growth factor receptor 2 （VEGFR2） gene polymorphism and the susceptibility of major depression disorders. Methods We collected peripheral blood samples from 274 Han patients diagnosed with unipolar depression and 273 age- and gender-matched Han healthy controls in Northeast of China. Single base primer extension assay （Snapshot） was used to detect genotype frequency and allele frequency of VEGFR2 ＋ 1416 T/A.χ^2 test was used to analyze the difference in the distribution of genotype and allele between the cases and the controls. Results There was a significant difference between the cases and the controls in the frequency distribution of VEGFR2 ＋ 1416 T/A genotype A/A（26. 3% vs. 16. 8% ） ,A/T（44. 9% vs. 54. 6% ） ,and T/T （28. 8% vs. 28.6% ）（χ^2 = 8. 219, P = 0. 016）. The frequency of VEGFR2 ＋ 1416 T/A allele of A and T were 48.7% and 51.3% in the cases and 44. 1% and 55. 9% in the controls,without significant difference between the two groups （χ^2 =2. 310,P =0. 129）. Conclusion The gene polymorphism of VEGFR2 ＋ 1416 T/A is correlated significantly with the incidence of unipolar depression.

关 键 词：抑郁症 血管内皮细胞生长因子 基因多态性 疾病易感性 

分 类 号：R749.4[医药卫生—神经病学与精神病学]