中国人群乳腺癌中MTA1蛋白表达及其临床意义的Meta分析  

Meta-analysis of the Expression of MTA1 Protein and its Clinical Significance in Breast Cancer of Chinese Population

作　　者：陈明芬[1] 郑建清[1] 苏菁菁[1] 白志刚[1] CHEN Ming-fen ZHENG Jian-qing SU Jing-jing et al.(The Second AWfliated Hospital of Fujian Medical University, Quanzhou 362000, Chin)

机构地区：[1]福建医科大学附属第二医院,福建泉州362000

出　　处：《中外医学研究》2017年第1期6-7,共2页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:利用Meta分析探讨乳腺癌组织中肿瘤转移相关基因蛋白1(MTA1)的表达及其与乳腺癌转移、侵袭之间的关系。方法:利用计算机检索万方数据库、维普数据库、中国生物医学文献数据库和CNKI等数据库,检索所需试验的参考文献,评价纳入研究的方法学质量,采用REVMAN 5.1.7软件进行Meta分析。结果:共10篇非随机病例对照试验被选入研究。Meta分析结果显示,乳腺癌组织中的MTA1蛋白表达阳性率为68.88%(383/556),明显高于正常乳腺组织的10.98%(47/428),差异具有统计学意义(P<0.05);淋巴结转移阳性组、肿瘤低分化组、Ⅲ~Ⅳ期组MTA1表达阳性率分别为86.85%(218/251)、82.89%(218/263)、82.65%(162/196),明显高于淋巴结转移阴性组、肿瘤中高分化组、Ⅰ~Ⅱ期组的56.90%(202/355)、54.27%(197/363)、61.66%(230/373),各组间差异均有统计学意义(P<0.05)。而雌激素受体阳性组MTA1表达阳性率为61.79%(173/280),与雌激素受体阴性组的69.81%(185/265)相比,差异无统计学意义(P>0.05)。结论:MTA1在乳腺癌组织中的表达高于正常乳腺组织,并且与乳腺癌的转移、侵袭能力相关,可以作为判断乳腺癌转移、侵袭能力的预后指标,有望成为乳腺癌基因治疗的新靶点。Objective： To explore the expression of metastasis-associated genes protein-1 （MTA-1） in breast cancer tissue and to investigate its relationship with the breast cancer metastasis and invasion by Meta-analysis.Method： The related studies in Wanfang database, VIP database, Chinese Biomedical Literature Database and CNKI database were searched, and the methodological quality of studies were evaluated.REVMAN 5.1.7 software was used in Meta-analysis.Result： A total of 10 non randomized case-control trial were selected for study.Meta-analysis showed that positive rates of the expressions of MTA1 in breast cancer tissues, were respectively 68.88%（383/556）, and significantly higher than 10.98%（47/428） of the normal breast tissue, the difference was statistically significant（P〈0.05）.Studies showed that the positive expression of MTA1 in the positive group of lymphatic metastasis was 86.85%（218/251）, significantly higher than 56.90%（202/355） in the negative group of lymphatic metastasis, the difference was statistically significant （P〈0.O5）.The positive rates of expression of MTA1 in the group of tumor poorly differentiated were respectively 82.89%（218/263）, and significantly higher than 54.27%（197/363） of well- differentiated tumors group, the difference was statistically significant（P〈0.05）.The positive rates of expression of MTA1 in the group of stage Ill-IV, were respectively 82.65%（162/196）, and significantly higher than 61.66%（230/373） of stage I-II, the difference was statistically significant （P〈0.05）.While, positive rate of the expression of MTA1 in the positive group of estrogen receptor was 61.79%（173/280）, compared with 69.81%（185/265） of estrogen receptor-negative group, the difference was not statistically significant（P〉0.05）.Conclusion： The expression of MTA1 is increased in breast cancer and positively correlated.MTA1 is related with the metastasis and invasion of breast cancer, which can be regarded as a prognostic indicator

关 键 词：乳腺癌 肿瘤转移相关基因蛋白1/MTA1 META分析 

分 类 号：R737.9[医药卫生—肿瘤]