微创方法提高大鼠拔牙效率的初步研究  

Preliminary research on improving the extraction efficiency of rats by minimally invasive method

作　　者：陈媛丽 许广杰 郭宇轩 肖维维 杨霞 侯锐 田磊 

机构地区：[1]军事口腔医学国家重点实验室,口腔疾病国家临床医学研究中心,陕西省口腔疾病临床医学研究中心,第四军医大学口腔医院颅颌面创伤外科,陕西西安710032 [2]军事口腔医学国家重点实验室,口腔疾病国家临床医学研究中心,陕西省口腔疾病临床医学研究中心,第四军医大学口腔医院口腔外科,陕西西安710032

出　　处：《口腔医学》2017年第1期15-18,共4页Stomatology

基　　金：国家自然科学基金(81202150/H2201);陕西省自然基金(2016JM8141);军事口腔医学国家重点实验室的自主研究课题(42413122G)

摘　　要：目的研究改进大鼠微创拔牙方法后的拔牙效果。方法将20只SD雌性大鼠随机分为两组,分别用微创方法(实验组)和常规方法(对照组)拔除两组左侧上、下颌6颗磨牙,观察术后大鼠存活情况、牙齿完整情况、拔牙区软组织的损伤情况。结果采用微创方法拔牙后大鼠存活率提高,牙冠破碎牙根断裂的发生率下降,拔牙创周围软组织损伤程度轻。结论微创拔牙方法为需要拔牙后建立大鼠模型的实验节省了时间和资源,有效保证了实验后续进行。Objects To study the effect of minimally invasive tooth extraction in rats. Methods Twenty SD female rats were randomly divided into two groups, the left six molars were extracted by conventional methods （control group） and minimally invasive method （ experimental group） respectively. Postoperative survival rates, teeth intactness and the injury of soft tissue in extraction sites were observed. Results Compared with control group, the rat survival rates increased in experimental group, the incidence of crown and root fracture decreased, and the degree of soft tissue injury in dental sockets was milder than the control group. Conclusion The minimally invasive extraction method can effectively save time and resources of animal experiments, which can ensure the following experiments to carry on smoothly.

关 键 词：牙拔除术 动物模型 微创技术 大鼠 

分 类 号：R782.11[医药卫生—口腔医学]