正畸牙齿移动中破骨细胞活动的影响因素  

Influence factors of osteoclast activity in orthodontic tooth movement

作　　者：米雁翎 刘婷[1,2] 蒋自然[1,2] 张凡[1,2] 

机构地区：[1]山东大学口腔医院正畸科,山东济南250012 [2]山东大学口腔医学院骨代谢实验室,山东济南250012

出　　处：《口腔医学》2017年第1期89-92,96,共5页Stomatology

摘　　要：正畸牙齿的移动依赖于牙周组织的改建,其中牙槽骨的改建主要依赖于破骨细胞和成骨细胞的功能活动。破骨细胞来源于造血干细胞,是一种高度分化的多核巨细胞,是正畸牙齿移动过程中压力侧骨吸收的主要功能细胞。破骨细胞的数量及功能是决定正畸牙齿移动效率的主要影响因素之一,其分化受各种全身性因素或局部因素直接或间接的影响,从而影响骨吸收改建,如激素水平,服用药物,局部加载的正畸力量,牙周状态以及各种细胞因子等,研究这些影响因素对于临床加速牙齿移动或增加支抗,减少不必要的牙齿移动均有一定的指导意义。Orthodontic tooth movement depends on the remodeling of periodontal tissues, and the alveolar bone remodeling depends mainly on the functional activities of osteoelast and osteoblast. Osteoclast derived from hematopoietic stem cells, is a kind of multinucleated, giant and highly differentiated cells, which is the main functional cell of bone resorption on the pressure side during orthodontic tooth movement. The number and function of osteociasts is one of the main factors determining the efficiency of orthodontic tooth movement. The differentiation of osteoclast is influenced by a variety of systemic factors or local factors directly or indirectly, thus affecting the absorption of bone remodeling, such as hormone levels, drugs, partially loaded orthodontic force, periodontal status and various cytokines. Research on these factors has certain guiding significance for accelerating tooth movement or increasing anchorage and reducing unnecessary tooth movement in clinic.

关 键 词：破骨细胞 正畸牙齿移动 激素 细胞因子 药物 

分 类 号：R783.5[医药卫生—口腔医学]