长链非编码RNA LINC00261在喉鳞状细胞癌中的表达及意义  

The expression of long non-coding RNA LINC00261 in laryngeal carcinoma tissue and their clinical significance

作　　者：张春明[1] 高伟[1] 吴勇延[1] 赵沁丽[1] 陈波[1] 刘青青[1] 李伟艳[1] 温树信[1] 王斌全[1] 

机构地区：[1]山西医科大学第一医院耳鼻咽喉科,太原030001

出　　处：《临床耳鼻咽喉头颈外科杂志》2017年第1期68-71,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨长链非编码RNA LINC00261在喉鳞状细胞癌中的表达及临床意义。方法:利用实时荧光定量PCR技术检测喉鳞状细胞癌组织及癌旁正常组织中LINC00261的表达情况,分析LINC00261的表达与喉鳞状细胞癌的临床分期、病理类型、组织学分级及淋巴结转移等临床病理参数之间的关系。结果:①与癌旁正常组织相比,喉癌组织中LINC00261的表达水平明显降低,差异有统计学意义(P<0.01);②在临床分型中,喉癌声门上型、声门型、声门下型3组中LINC00261的表达水平均差异无统计学意义(P>0.05);在组织学分型中,LINC00261表达量在低分化喉癌组织中与高、中分化喉癌组织中差异无统计学意义(P>0.05);在T分期分组中,LINC00261在T_1+T_2组的表达显著高于T_3+T_4组(P<0.05);在有无淋巴结转移分组中,无淋巴结转移的喉癌组织中LINC00261的表达明显高于有淋巴结转移组织(P<0.05)。结论:LINC00261表达下调可能与喉癌的发生有关,LINC00261表达量可能与喉癌的T分期及淋巴结转移相关。Objective：To investigate the expression of LINC00261 in laryngeal carcinoma and to discuss their relevance and the roles in carcinogenesis and development of laryngeal carcinoma.Method：The expressions of LINC00261 in laryngeal carcinoma tissue and paired adjacent normal tissue was determined by real-time PCR.The relationship between the expressions of LINC00261 and the clinic pathological characteristics including clinical stage,pathological type,histological grade and lymph node metastasis in LSCC was analysed according to the clinical data.Result：①The expression of LINC00261 was significantly decreased in the LSCC tissue compared with the normal laryngeal tissue（P〈0.01）.②In clinical stage grouping,there were no statistical differences of the quantity of LINC00261 expression among supraglottic,glottic and subglottic LSCC（P〉0.05）.In histological differentiation grouping,LINC00261 had no significant changes in poorly differentiated LSCC compared with the well and moderately differentiated LSCC（P〉0.05）.In histological grade grouping,the expression of LINC00261 in T1＋T2 stages was significantly higher than T3 ＋T4 stages（P〈0.05）.Moreover,the expression of LINC00261 in LSCC with lymph node metastasis was significantly lower than that without of lymph node metastasis（P〈0.05）.Conclusion：Down regulation of LINC00261 in laryngeal carcinoma may contribute to the carcinogenesis and development of laryngeal carcinoma.The decreased expression of LINC00261 maybe relative to T term degree and lymphamatic metastasis of laryngeal carcinoma.

关 键 词：喉肿瘤 癌 鳞状细胞 长链非编码RNA LINC00261 侵袭 转移 

分 类 号：R739.6[医药卫生—肿瘤]