应用奥洛他定滴眼液等药物联合治疗过敏性结膜炎疗效分析  

Treatment for allergic conjunctivitis with olopatadine eye drops and other therapies:a Meta-analysis

作　　者：张健[1] 杨伊琳[2] 

机构地区：[1]汕头大学.香港中文大学联合汕头国际眼科中心,中国广东省汕头市515041 [2]中国广东省汕头市中心医院儿科,515000

出　　处：《国际眼科杂志》2017年第2期238-242,共5页International Eye Science

摘　　要：目的:系统评价应用奥洛他定滴眼液联合治疗过敏性结膜炎的临床疗效和安全性。方法:计算机检索Pub Med、EMbase、Cochrane Library、维普中文科技期刊数据库、中国知网、万方数据库,查找国内外应用奥洛他定滴眼液联合治疗比较单独奥洛他定治疗过敏性结膜炎患者的随机对照试验(RCT),检索时限截至2016-08。国外未查到相关文献。根据纳入与排除标准纳入可分析的数据,采用Review Manager 5.3软件进行Meta分析。结果:最终纳入28个RCT,共计3 568例患者,其中治疗组1 799例,对照组1 769例。Meta分析结果显示:应用奥洛他定滴眼液联合治疗过敏性结膜炎的临床疗效均优于奥洛他定滴眼液单独治疗,其差异均有统计学意义[OR=3.54,95%CI(2.71~4.61),P<0.001]。结论:应用奥洛他定滴眼液联合治疗过敏性结膜炎患者可使症状与体征显著改善,提高治疗的有效率。受纳入研究质量和数量所限,上述结论尚需进一步开展严格设计的随机双盲对照试验加以验证。AIM：To systemically evaluate the clinical efficacy and safety of treating allergic conjunctivitis with olopatadine eye drops and other therapies.METHODS：We performed a comprehensive search for the randomized controlled trials（RCTs） about the olopatadine eye drops and other therapies vs.olopatadine eye drops monotherapy for treating allergic conjunctivitis published by April,2016 from PubMed,EM base,Cochrane Library,VIP Chinese periodical Database,CNKI and Wan Fang Chinese periodical Database.Studies obtained from eligible database were filtered according to the criteria,and data were retrieved from those studies for further analysis.Then we performed a Meta-analysis using RevMan 5.3 software.RESULTS：A total of 28 RCTs were included.Among all3568 patients involved in,1799 were in the treatment group,while the other 1769 were in the control group.The results of Meta- analysis showed that the olopatadine eye drops and other therapies was superior to monotherapy for patients with allergic conjunctivitis in clinical effects[OR=3.54,95%CI（2.71,4.61）,P〈0.001].CONCLUSION：The existing evidence supports that the prognosis of the olopatadine eye drops and other therapies is better than olopatadine eye drops monotherapy for treating allergic conjunctivitis.For the quality and quantity limitations of the included studies,more well-designed and double blind RCTs are required to further prove this conclusion.

关 键 词：奥洛他定滴眼液 联合治疗 过敏性结膜炎 META分析 

分 类 号：R777.31[医药卫生—眼科]