围绝经期女性胃食管反流病的临床特征分析  

Analysis on clinical characteristics of gastroesophageal reflux disease in perimenopausal women

作　　者：陈萍[1] 李霞[1] 杨朝霞[1] 

机构地区：[1]重庆医科大学附属第二医院消化内科,重庆400010

出　　处：《重庆医学》2017年第3期289-291,295,共4页Chongqing medicine

基　　金：国家自然科学青年基金项目(81101827)

摘　　要：目的分析围绝经期女性胃食管反流病(GERD)的临床特点,提高对该期女性GERD的认识。方法对该院2014年1月至2015年12月门诊及住院确诊GERD的246例患者的临床资料、胃镜检查及24h食管阻抗-pH监测结果进行回顾性分析;按性别将患者分为女性组和男性组,根据月经情况又将女性组分为围绝经期组和非围绝经组2个亚组,对比分析各组患者的临床特点。结果女性组NERD所占比例较男性组高,以非典型症状为主诉的发生率也高于男性组,差异均有统计学意义(P<0.05);女性组中围绝经期组、非围绝经组反酸发生率均低于男性组(P<0.05);围绝经期组弱酸反流次数与非围绝经组和男性组比较差异均有统计学意义(P<0.05)。结论围绝经期女性GERD多以非典型症状为主要表现,内镜、24h食管阻抗-pH联合监测是诊断围绝经期女性GERD的选择。Objective To investigate the clinical features of gastroesophageal reflux disease（GERD）and improve recognition of GERD among perimenopausal women.Methods The clinical data,gastroscopic examination and and 24 hmultichannel intraluminal esophageal impedance-pH monitoring of 246 outpatients and inpatients with definitely diagnosed GERD in our hospital from January 2014 to December 2015 were analyzed retrospectively;they were divided into the female group and male group according to gender,then based on the menstruation situation,the female group was re-divided into perimenopause subgroup and non-perimenopause subgroup.The clinical features were compared among various groups.Results The proportion of NERD in the female group was higher than that in the male group and the occurrence rate of atypical symptoms as the main complaint was also higher than that in the male group,the differences were statistically different（P〈0.05）;in the perimenopause subgroup and non-perimenopause subgroup of female group,the incidence rate of acid reflux was lower than that in the male group（P〈0.05）;in the perimenopause subgroup,the number of weakly acid reflux episodes was more than that in the non-perimenopause subgroup and male group,the difference was statistically significant（P〈0.05）.Conclusion The atypical symptoms are the main manifestation in perimenopausal women with GERD.The combined monitoring of endoscopy plus 24 hambulatory impedance-pH may be a better choice for diagnosing perimenopausal women GERD.

关 键 词：胃食管反流 食管炎 围绝经期 性别因素 24h食管阻抗-pH监测 

分 类 号：R571[医药卫生—消化系统]